F C Tortella
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Explore the profile of F C Tortella including associated specialties, affiliations and a list of published articles.
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Articles
93
Citations
756
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Recent Articles
1.
Chen R, Yao C, Lu X, Jiang Z, Whipple R, Liao Z, et al.
Neuroscience
. 2005 Aug;
135(1):191-201.
PMID: 16084648
Neurotoxicity in primary neurons was induced using hypoxia/hypoglycemia (H/H), veratridine (10microM), staurosporine (1microM) or glutamate (100microM), which resulted in 72%, 67%, 75% and 66% neuronal injury, respectively. 3-Aminopyridine-2-carboxaldehyde thiosemicarbazone (PAN-811;...
2.
Yao C, Williams A, Hartings J, Lu X, Tortella F, Dave J
Life Sci
. 2005 May;
77(10):1116-29.
PMID: 15878599
Change in sodium channel (NaCh) activity can play a role in reorganization, recovery, or possibly excitotoxic damage after CNS injury. Alteration of sodium channel function has been reported to occur...
3.
Williams A, Tortella F, Lu X, Moreton J, Hartings J
J Pharmacol Exp Ther
. 2004 May;
311(1):220-7.
PMID: 15140918
Nonconvulsive seizures (NCSs) after traumatic and ischemic brain injury are often refractory to antiepileptic drug therapy and are associated with a decline in patient outcome. We recently characterized an in...
4.
Dave J, Lin Y, Ved H, Koenig M, Clapp L, Hunter J, et al.
Neurotox Res
. 2004 Jan;
3(4):381-95.
PMID: 14715468
The present study investigated the effects of RS-100642-198 (a novel sodium channel blocker), and two related compounds (mexiletine and QX-314), in in vitro models of neurotoxicity. Neurotoxicity was produced in...
5.
Berti R, Williams A, Velarde L, Moffett J, Elliott P, Adams J, et al.
Neurotox Res
. 2004 Jan;
5(7):505-14.
PMID: 14715434
Anti-inflammatory treatment with the proteasome inhibitor MLN519 has been previously reported to be neuroprotective against ischemic brain injury in rats. These effects have been related to inhibition of the transcription...
6.
Moffett J, Price R, Anderson S, Sipos M, Moran A, Tortella F, et al.
Cell Mol Life Sci
. 2003 Nov;
60(10):2266-71.
PMID: 14618272
The objective of the present study was to determine levels of DNA fragmentation in blood leukocytes from guinea pigs by single-cell gel electrophoresis (comet assay) after exposure to the chemical...
7.
Williams A, Ling G, Berti R, Moffett J, Yao C, Lu X, et al.
Exp Brain Res
. 2003 Sep;
153(1):16-26.
PMID: 12955387
Delayed cell death following ischemic brain injury has been linked to alterations in gene expression. In this study we have evaluated the upregulation of several genes associated with delayed cell...
8.
Williams A, Berti R, Yao C, Price R, Velarde L, Koplovitz I, et al.
Neurosci Lett
. 2003 Sep;
349(3):147-50.
PMID: 12951190
Effective treatments to improve survivability following exposure to the nerve agent soman have been established and are currently available. Unfortunately, electrographic brain seizures, neuroinflammation and brain cell death are still...
9.
Yao C, Williams A, Lu X, Price R, Cunningham B, Berti R, et al.
Neurotox Res
. 2003 Jul;
5(4):245-53.
PMID: 12835116
In this study we evaluated the expression of five sodium channel (NaCh) Alpha-subunit genes after transient middle cerebral artery occlusion (MCAo) in the rat and the effects of treatment with...
10.
Yao C, Williams A, Cui P, Berti R, Hunter J, Tortella F, et al.
Neurotox Res
. 2003 Jun;
4(1):67-75.
PMID: 12826495
This study investigated the effects of brain ischemia on sodium channel gene (NaCh) expression in rats. Using quantitative RT-PCR, our findings demonstrated the expression ratio of NaCh genes in normal...