F C Tortella
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Explore the profile of F C Tortella including associated specialties, affiliations and a list of published articles.
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93
Citations
756
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Recent Articles
11.
Lu X, Williams A, Tortella F
Neuropathol Appl Neurobiol
. 2002 Mar;
27(6):481-95.
PMID: 11903931
Electroencephalography (EEG) has a long history in clinical evaluations of cerebrovascular disease. Distinct EEG abnormalities, such as increased slow delta activity, voltage depression and epileptiform discharge, have been identified in...
12.
Bao W, Williams A, Faden A, Tortella F
Brain Res
. 2001 Dec;
922(2):173-9.
PMID: 11743947
Activation of group I metabotropic glutamate receptors (mGluR) has been implicated in the pathophysiology of acute central nervous system injury. However, the relative roles of the two group I subtypes,...
13.
Williams A, Lu X, Slusher B, Tortella F
J Pharmacol Exp Ther
. 2001 Sep;
299(1):48-57.
PMID: 11561062
We have evaluated the effects of the N-acetylated-alpha-linked acidic dipeptidase (NAALADase) inhibitor, GPI5232 [2-[(pentafluorophenylmethyl)hydroxyphosphinyl]methyl)-pentanedioic acid], to not only decrease brain injury but also to alter the inherent electroencephalographic (EEG) changes...
14.
Tortella F, Lin Y, Ved H, Slusher B, Dave J
Eur J Pharmacol
. 2000 Aug;
402(1-2):31-7.
PMID: 10940354
The present study examined the neuroprotective actions of the N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) inhibitor 2-(phosphonomethyl)pentanedioic acid (2-PMPA) in four in vitro models of neurotoxicity. Using neuron-enriched primary cultures derived from rat...
15.
Phillips J, Williams A, Adams J, Elliott P, Tortella F
Stroke
. 2000 Jul;
31(7):1686-93.
PMID: 10884474
Background And Purpose: Reperfusion brain injury after cerebral ischemia is associated with a developing inflammatory response at the site of infarction. Proteasome inhibitors block nuclear factor-kappaB activation and provide anti-inflammatory...
16.
Williams A, Dave J, Phillips J, Lin Y, McCabe R, Tortella F
J Pharmacol Exp Ther
. 2000 Jun;
294(1):378-86.
PMID: 10871336
Conantokin-G (Con-G), a 17-amino-acid peptide derived from marine snails and a potent N-methyl-D-aspartate (NMDA) antagonist, was evaluated for its neuroprotective properties in vitro and in vivo. In primary cerebellar neurons,...
17.
Slusher B, Vornov J, Thomas A, Hurn P, Harukuni I, Bhardwaj A, et al.
Nat Med
. 1999 Dec;
5(12):1396-402.
PMID: 10581082
We describe here a new strategy for the treatment of stroke, through the inhibition of NAALADase (N-acetylated-alpha-linked-acidic dipeptidase), an enzyme responsible for the hydrolysis of the neuropeptide NAAG (N-acetyl-aspartyl-glutamate) to...
18.
Tortella F, Britton P, Williams A, Lu X, Newman A
J Pharmacol Exp Ther
. 1999 Sep;
291(1):399-408.
PMID: 10490930
AHN649, an analog of dextromethorphan (DM) and a relatively selective low-affinity N-methyl-D-aspartate antagonist, was evaluated for neuroprotective effects using the rat intraluminal filament model of temporary middle cerebral artery occlusion....
19.
Witkin J, Gasior M, Heifets B, Tortella F
J Pharmacol Exp Ther
. 1999 Apr;
289(2):703-11.
PMID: 10215643
Convulsions associated with cocaine abuse can be life threatening and resistant to standard emergency treatment. Cocaine (75 mg/kg, i. p.) produced clonic convulsions in approximately 90% of male, Swiss-Webster mice....
20.
Lu X, Tortella F, Ved H, Garcia G, Dave J
Neuroreport
. 1997 Oct;
8(13):2925-9.
PMID: 9376532
We investigated the dose-response and time-course of c-fos antisense oligodeoxynucleotide (ASO) treatment against excitatory amino acid (EAA)-induced neurotoxicity in rat hippocampal neurons. Glutamate (in vitro) or NMDA (in vivo) produced...