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F C Luft

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Articles 635
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Luft F
Internist (Berl) . 2021 Feb; 62(3):223-235. PMID: 33595671
A genetic influence on blood pressure was demonstrated more than 100 years ago and a simple Mendelian inheritance was initially presumed. Platt and Pickering conducted a lively debate on this...
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Wiig H, Luft F, Titze J
Acta Physiol (Oxf) . 2017 Dec; 222(3). PMID: 29193764
The role of salt in the pathogenesis of arterial hypertension is not well understood. According to the current understanding, the central mechanism for blood pressure (BP) regulation relies on classical...
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Haufe S, Engeli S, Kaminski J, Witt H, Rein D, Kamlage B, et al.
Nutr Metab Cardiovasc Dis . 2017 Sep; 27(10):858-864. PMID: 28958691
Background & Aims: 3-Hydroxyisobutyrate (3-HIB), a catabolic intermediate of the BCAA valine, which stimulates muscle fatty acid uptake, has been implicated in the pathogenesis of insulin resistance. We tested the...
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Haufe S, Witt H, Engeli S, Kaminski J, Utz W, Fuhrmann J, et al.
Nutr Metab Cardiovasc Dis . 2016 May; 26(7):637-642. PMID: 27134061
Background & Aims: Amino acids may interfere with insulin action, particularly in obese individuals. We hypothesized that increased circulating branched-chain and aromatic amino acids herald insulin resistance and ectopic fat...
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Kettritz R, Luft F
Internist (Berl) . 2015 Jun; 56(7):745-52. PMID: 26036655
The maintenance of water and electrolyte homeostasis is of enormous importance for the functioning of cells and tissues. A number of therapeutic procedures intentionally or unintentionally influence important regulatory mechanisms...
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Luft F
Internist (Berl) . 2015 Feb; 56(3):224-9. PMID: 25668441
When blood pressure is poorly controlled despite treatment with a diuretic and two antihypertensive drugs at adequate doses, the hypertension is termed resistant. The prevalence of resistant hypertension is increasing....
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Schroeder C, Heusser K, Zoerner A, Grosshennig A, Wenzel D, May M, et al.
Clin Pharmacol Ther . 2014 Feb; 95(6):601-7. PMID: 24509430
Hyperpolarization-activated, cyclic nucleotide-gated 4 (HCN4) channels comprise the final pathway for autonomic heart rate (HR) regulation. We hypothesized that HCN4 inhibition could reverse autonomic imbalance in a human model of...
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Kettritz R, Hinrichs C, Althoff C, Luft F
J R Coll Physicians Edinb . 2012 Jun; 42(2):128-30. PMID: 22693697
Modern diagnostic possibilities pose a number of challenges. When is a precise genetic diagnosis justifiable in today's climate of cost-cutting? We would like to pose that question to Sir William...
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Luedtke A, Boschmann M, Colpe C, Engeli S, Adams F, Birkenfeld A, et al.
Horm Metab Res . 2012 Jan; 44(4):306-11. PMID: 22274718
Type 2 familial partial lipodystrophy (FPLD2) patients show impaired glucose and lipid metabolism resulting from lipodystrophic 'lipid pressure' and an intrinsic defect in skeletal muscle metabolism. Since mutated lamin A...