Evan R Simpson
Overview
Explore the profile of Evan R Simpson including associated specialties, affiliations and a list of published articles.
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Articles
118
Citations
3773
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Recent Articles
1.
Bernasochi G, Bell J, Simpson E, Delbridge L, Boon W
Compr Physiol
. 2019 Mar;
9(2):457-475.
PMID: 30873596
As adipose tissue depots are active endocrine organs, they secrete a variety of hormones (including estrogens from white adipose) and inflammatory mediators, which have important implications in numerous obesity-associated diseases....
2.
Simpson E, Brown K
Expert Rev Endocrinol Metab
. 2019 Feb;
6(3):383-395.
PMID: 30754106
After the menopausal transition, the ovaries cease to make estrogens, yet the incidence of breast cancer increases and the majority of these tumors are estrogen receptor positive. So, where is...
3.
Dall G, Vieusseux J, Korach K, Arao Y, Hewitt S, Hamilton K, et al.
Stem Cell Reports
. 2017 Jan;
8(2):417-431.
PMID: 28132885
Estrogen stimulates breast development during puberty and mammary tumors in adulthood through estrogen receptor-α (ERα). These effects are proposed to occur via ERα luminal cells and not the mammary stem...
4.
Zahid H, Simpson E, Brown K
Curr Opin Pharmacol
. 2016 Nov;
31:90-96.
PMID: 27875786
Obesity is associated with an increased risk of estrogen-dependent breast cancer after menopause. Adipose tissue undergoes important changes in obesity due to excess storage of lipids, leading to adipocyte cell...
5.
Hewitson T, Boon W, Simpson E, Smith E, Samuel C
Life Sci
. 2016 Jul;
158:130-6.
PMID: 27373424
Aims: Controversy surrounds the gender basis of progression in chronic kidney disease. Unfortunately, most experimental studies addressing this question do not distinguish between direct effects of estrogen and indirect activation...
6.
Van Sinderen M, Steinberg G, Jorgensen S, Honeyman J, Chow J, Simpson E, et al.
J Steroid Biochem Mol Biol
. 2016 Jun;
170:39-48.
PMID: 27353462
We investigated the effects of estrogens on glucose homeostasis using the Aromatase Knockout (ArKO) mouse, which is unable to convert androgens into estrogens. The ArKO mouse is a model of...
7.
Ham S, Brown K, Simpson E, Meachem S
Reprod Fertil Dev
. 2016 Mar;
PMID: 26946412
Although oestrogens are essential for spermatogenesis and their biosynthesis is dependent on aromatase expression, the molecular mechanism of aromatase regulation is poorly understood. Our laboratory has demonstrated that liver kinase...
8.
Wang X, Simpson E, Brown K
Cancer Res
. 2015 Nov;
75(23):5001-7.
PMID: 26573797
The tumor suppressor p53 has established functions in cancer. Specifically, it has been shown to cause cell-cycle arrest and apoptosis in response to DNA damage. It is also one of...
9.
Haverfield J, Stanton P, Loveland K, Zahid H, Nicholls P, Olcorn J, et al.
Reprod Fertil Dev
. 2015 Oct;
29(3):609-620.
PMID: 26488911
A dynamic partnership between follicle-stimulating hormone (FSH) and activin is required for normal Sertoli cell development and fertility. Disruptions to this partnership trigger Sertoli cells to deviate from their normal...
10.
Van Sinderen M, Steinberg G, Jorgensen S, Honeyman J, Chow J, Herridge K, et al.
PLoS One
. 2015 Aug;
10(8):e0136143.
PMID: 26317527
The maintenance of glucose homeostasis within the body is crucial for constant and precise performance of energy balance and is sustained by a number of peripheral organs. Estrogens are known...