Evan J van Aalst
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Explore the profile of Evan J van Aalst including associated specialties, affiliations and a list of published articles.
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9
Citations
20
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Recent Articles
1.
van Aalst E, Wylie B
Protein Sci
. 2024 Dec;
34(1):e70013.
PMID: 39723881
G protein Coupled Receptors (GPCRs) are the largest family of cell surface receptors in humans. Somatic mutations in GPCRs are implicated in cancer progression and metastasis, but mechanisms are poorly...
2.
van Aalst E, Yekefallah M, A M van Beekveld R, Breukink E, Weingarth M, Wylie B
J Struct Biol X
. 2024 Jun;
9:100101.
PMID: 38883399
Physical properties of biological membranes directly or indirectly govern biological processes. Yet, the interplay between membrane and integral membrane proteins is difficult to assess due to reciprocal effects between membrane...
3.
Yekefallah M, van Aalst E, A M van Beekveld R, Eason I, Breukink E, Weingarth M, et al.
J Am Chem Soc
. 2024 Feb;
146(7):4421-4432.
PMID: 38334076
Lipids adhere to membrane proteins to stimulate or suppress molecular and ionic transport and signal transduction. Yet, the molecular details of lipid-protein interaction and their functional impact are poorly characterized....
4.
Mishra S, van Aalst E, Wylie B, Jeannine Brady L
Front Mol Biosci
. 2023 Oct;
10:1264454.
PMID: 37867558
YidC belongs to an evolutionarily conserved family of insertases, YidC/Oxa1/Alb3, in bacteria, mitochondria, and chloroplasts, respectively. Unlike Gram-negative bacteria, Gram-positives including harbor two paralogs of YidC. The mechanism for paralog-specific...
5.
van Aalst E, Jang J, Halligan T, Wylie B
J Biomol NMR
. 2023 Jul;
77(4):191-202.
PMID: 37493866
In protein nuclear magnetic resonance (NMR), chemical shift assignment provides a wealth of information. However, acquisition of high-quality solid-state NMR spectra depends on protein-specific dynamics. For membrane proteins, bilayer heterogeneity...
6.
Ding X, Unruh D, Ma L, van Aalst E, Reinheimer E, Wylie B, et al.
Angew Chem Int Ed Engl
. 2023 Jun;
62(33):e202306198.
PMID: 37369627
Achieving substantial anisotropic thermal expansion (TE) in solid-state materials is challenging as most materials undergo volumetric expansion upon heating. Here, we describe colossal, anisotropic TE in crystals of an organic...
7.
van Aalst E, McDonald C, Wylie B
J Chem Inf Model
. 2023 May;
63(10):3068-3085.
PMID: 37127541
Cholesterol directs the pathway of ligand-induced G protein-coupled receptor (GPCR) signal transduction. The GPCR C-C motif chemokine receptor 3 (CCR3) is the principal chemotactic receptor for eosinophils, with roles in...
8.
Yekefallah M, Rasberry C, van Aalst E, Browning H, Amani R, Versteeg D, et al.
ACS Omega
. 2022 Dec;
7(48):43621-43634.
PMID: 36506180
Potassium (K) channels are regulated in part by allosteric communication between the helical bundle crossing, or inner gate, and the selectivity filter, or outer gate. This network is triggered by...
9.
van Aalst E, Borcik C, Wylie B
Biochim Biophys Acta Biomembr
. 2022 Feb;
1864(6):183891.
PMID: 35217001
Membrane proteins and polycyclic lipids like cholesterol and hopanoids coordinate phospholipid bilayer ordering. This phenomenon manifests as partitioning of the liquid crystalline phase into liquid-ordered (L) and liquid-disordered (L) regions....