Evan J Olson
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Explore the profile of Evan J Olson including associated specialties, affiliations and a list of published articles.
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10
Citations
317
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Recent Articles
1.
Ming Yip H, Cheng S, Olson E, Crone M, Maerkl S
Proc Natl Acad Sci U S A
. 2023 Jan;
120(2):e2212151120.
PMID: 36608289
Cells cope with and adapt to ever-changing environmental conditions. Sophisticated regulatory networks allow cells to adjust to these fluctuating environments. One such archetypal system is the Pho regulon. When external...
2.
Shahein A, Lopez-Malo M, Istomin I, Olson E, Cheng S, Maerkl S
Nat Commun
. 2022 Sep;
13(1):5273.
PMID: 36071116
Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in...
3.
Gerhardt K, Rao S, Olson E, Igoshin O, Tabor J
Nat Commun
. 2021 Nov;
12(1):6957.
PMID: 34845228
Gene expression noise can reduce cellular fitness or facilitate processes such as alternative metabolism, antibiotic resistance, and differentiation. Unfortunately, efforts to study the impacts of noise have been hampered by...
4.
Ong N, Olson E, Tabor J
ACS Synth Biol
. 2017 Nov;
7(1):240-248.
PMID: 29091422
Optogenetics is a technology wherein researchers combine light and genetically engineered photoreceptors to control biological processes with unrivaled precision. Near-infrared (NIR) wavelengths (>700 nm) are desirable optogenetic inputs due to...
5.
Olson E, Tzouanas C, Tabor J
Mol Syst Biol
. 2017 Apr;
13(4):926.
PMID: 28438832
Optogenetics combines externally applied light signals and genetically engineered photoreceptors to control cellular processes with unmatched precision. Here, we develop a mathematical model of wavelength- and intensity-dependent photoconversion, signaling, and...
6.
Gerhardt K, Olson E, Castillo-Hair S, Hartsough L, Landry B, Ekness F, et al.
Sci Rep
. 2016 Nov;
6:35363.
PMID: 27805047
In optogenetics, researchers use light and genetically encoded photoreceptors to control biological processes with unmatched precision. However, outside of neuroscience, the impact of optogenetics has been limited by a lack...
7.
Castillo-Hair S, Sexton J, Landry B, Olson E, Igoshin O, Tabor J
ACS Synth Biol
. 2016 Apr;
5(7):774-80.
PMID: 27110723
Flow cytometry is widely used to measure gene expression and other molecular biological processes with single cell resolution via fluorescent probes. Flow cytometers output data in arbitrary units (a.u.) that...
8.
Olson E, Tabor J
Nat Chem Biol
. 2014 Jun;
10(7):502-11.
PMID: 24937068
Systems biologists aim to understand how organism-level processes, such as differentiation and multicellular development, are encoded in DNA. Conversely, synthetic biologists aim to program systems-level biological processes, such as engineered...
9.
Olson E, Hartsough L, Landry B, Shroff R, Tabor J
Nat Methods
. 2014 Mar;
11(4):449-55.
PMID: 24608181
Gene circuits are dynamical systems that regulate cellular behaviors, often using protein signals as inputs and outputs. Here we have developed an optogenetic 'function generator' method for programming tailor-made gene...
10.
Olson E, Tabor J
Curr Opin Chem Biol
. 2012 Jul;
16(3-4):300-6.
PMID: 22766485
Synthetic biology is improving our understanding of and ability to control living organisms. To date, most progress has been made by engineering gene expression. However, computational and genetically encoded tools...