Evan G Pappas
Overview
Explore the profile of Evan G Pappas including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
14
Citations
202
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Selck C, Jhala G, De George D, Kwong C, Christensen M, Pappas E, et al.
Proc Natl Acad Sci U S A
. 2024 Jan;
121(6):e2315419121.
PMID: 38285952
Persistent antigen exposure results in the differentiation of functionally impaired, also termed exhausted, T cells which are maintained by a distinct population of precursors of exhausted T (T) cells. T...
2.
Pappas E, Kershaw M, Slaney C
Cancers (Basel)
. 2023 Feb;
15(4).
PMID: 36831663
This Special Issue reminds us that, although incredible developments have occurred in the field of cancer immunotherapy, there is still plenty of room for improvement [...].
3.
Ge T, Phung A, Jhala G, Trivedi P, Principe N, De George D, et al.
Clin Transl Immunology
. 2022 Nov;
11(11):e1425.
PMID: 36325490
Objectives: Immune checkpoint inhibitors have achieved clinical success in cancer treatment, but this treatment causes immune-related adverse events, including type 1 diabetes (T1D). Our aim was to test whether a...
4.
Jhala G, Krishnamurthy B, Brodnicki T, Ge T, Akazawa S, Selck C, et al.
Cell Rep
. 2022 Apr;
39(4):110747.
PMID: 35476975
Interferon gamma (IFNγ) is a proinflammatory cytokine implicated in autoimmune diseases. However, deficiency or neutralization of IFNγ is ineffective in reducing disease. We characterize islet antigen-specific T cells in non-obese...
5.
Yang C, Ann-Onda D, Lin X, Fynch S, Nadarajah S, Pappas E, et al.
Mol Metab
. 2021 Dec;
55:101413.
PMID: 34890851
Objectives: Loss of functional β-cell mass is a key factor contributing to poor glycemic control in advanced type 2 diabetes (T2D). We have previously reported that the inhibition of the...
6.
Jhala G, Selck C, Chee J, Kwong C, Pappas E, Thomas H, et al.
Front Immunol
. 2021 Apr;
12:645817.
PMID: 33841427
T-cell responses to insulin and its precursor proinsulin are central to islet autoimmunity in humans and non-obese diabetic (NOD) mice that spontaneously develop autoimmune diabetes. Mice have two proinsulin genes...
7.
Akazawa S, Mackin L, Jhala G, Fynch S, Catterall T, Selck C, et al.
Diabetologia
. 2021 Jan;
64(4):878-889.
PMID: 33483762
Aims/hypothesis: Stimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type I IFN production in innate immune cells....
8.
Ge T, Jhala G, Fynch S, Akazawa S, Litwak S, Pappas E, et al.
Front Immunol
. 2020 Dec;
11:588543.
PMID: 33343569
Cytokines that signal through the JAK-STAT pathway, such as interferon-γ (IFN-γ) and common γ chain cytokines, contribute to the destruction of insulin-secreting β cells by CD8 T cells in type...
9.
Bensellam M, Shi Y, Chan J, Laybutt D, Chae H, Abou-Samra M, et al.
Diabetologia
. 2019 Oct;
62(12):2273-2286.
PMID: 31624901
Aims/hypothesis: The mechanisms responsible for beta cell compensation in obesity and for beta cell failure in type 2 diabetes are poorly defined. The mRNA levels of several metallothionein (MT) genes...
10.
Wali J, Galic S, Tan C, Gurzov E, Frazier A, Connor T, et al.
Cell Death Differ
. 2017 Oct;
25(1):217-225.
PMID: 29053141
BCL-2 proteins are known to engage each other to determine the fate of a cell after a death stimulus. However, their evolutionary conservation and the many other reported binding partners...