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Eun-Ah Bae

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Articles 55
Citations 1256
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Recent Articles
1.
Ahn T, Bae E, Seo H
Mol Ther . 2024 Apr; 32(6):1617-1627. PMID: 38582965
T cell exhaustion, which is observed in various chronic infections and malignancies, is characterized by elevated expression of multiple inhibitory receptors, impaired effector functions, decreased proliferation, and reduced cytokine production....
2.
Hope J, Otero D, Bae E, Stairiker C, Palete A, Faso H, et al.
Cell Rep . 2023 Apr; 42(5):112436. PMID: 37115668
PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with...
3.
Lu Z, Bae E, Verginadis I, Zhang H, Cho C, McBrearty N, et al.
Cancer Immunol Immunother . 2022 Sep; 72(4):815-826. PMID: 36063172
Immune suppressive factors of the tumor microenvironment (TME) undermine viability and exhaust the activities of the intratumoral cytotoxic CD8 + T lymphocytes (CTL) thereby evading anti-tumor immunity and decreasing the...
4.
Hope J, Zhao M, Stairiker C, Kiernan C, Carey A, Mueller Y, et al.
J Immunol . 2022 Jan; 208(3):603-617. PMID: 35022277
MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the immune system and immune responses. Using miRNA microarray profiling, we...
5.
Koh C, Kim I, Shin K, Jeon I, Song B, Lee J, et al.
Cancer Immunol Res . 2020 Mar; 8(5):698-709. PMID: 32122993
Although treatment with the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) agonistic antibody (DTA-1) has shown antitumor activity in various tumor models, the underlying mechanism is not fully understood. Here,...
6.
Song B, Lee J, Park Y, Kim I, Kim B, Shin K, et al.
FASEB J . 2020 Jan; 34(3):4462-4481. PMID: 31989715
Myeloid progenitor cells have generally been considered the predominant source of myeloid cells under steady-state conditions. Here we show that NK cells contributed to a myeloid cell lineage pool in...
7.
Shin K, Jeon I, Kim B, Kim I, Park Y, Koh C, et al.
Front Immunol . 2019 Sep; 10:1887. PMID: 31474983
Monocyte-derived dendritic cells (moDCs) have been shown to robustly expand during infection; however, their roles in anti-infectious immunity remain unclear. Here, we found that moDCs were dramatically increased in the...
8.
Hope J, Stairiker C, Bae E, Otero D, Bradley L
Front Immunol . 2019 Aug; 10:1595. PMID: 31379821
Effective adaptive immune responses are characterized by stages of development and maturation of T and B cell populations that respond to disturbances in the host homeostasis in cases of both...
9.
Bae E, Seo H, Kim I, Jeon I, Kang C
Arch Pharm Res . 2019 Mar; 42(7):543-548. PMID: 30859410
Cancer immunotherapy has emerged as an effective therapeutic strategy to treat cancer. Among diverse immune populations, invariant natural killer T (iNKT) cells have shown potent antitumor activity by linking innate...
10.
Kim I, Koh C, Jeon I, Shin K, Kang T, Bae E, et al.
Cancer Immunol Res . 2019 Feb; 7(3):498-509. PMID: 30728152
GM-CSF as an adjuvant has been shown to promote antitumor immunity in mice and humans; however, the underlying mechanism of GM-CSF-induced antitumor immunity remains incompletely understood. In this study, we...