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Eun-Ae Shin

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Articles 12
Citations 294
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Recent Articles
1.
Kim J, Kim H, Kim W, Lee E, Kim S, Kim T, et al.
Signal Transduct Target Ther . 2025 Jan; 10(1):15. PMID: 39828766
Dynamic communication between hepatocytes and the environment is critical in hepatocellular carcinoma (HCC) development. Clinical immunotherapy against HCC is currently unsatisfactory and needs more systemic considerations, including the identification of...
2.
Pinanga Y, Pyo K, Shin E, Lee H, Lee E, Kim W, et al.
Life Sci . 2024 Oct; 358:123164. PMID: 39454995
Gut microbiome dysbiosis is involved in non-alcoholic fatty liver disease (NAFLD) development. Hepatic transmembrane 4 L six family member 5 (TM4SF5) overexpression promotes NAFLD. However, how gut microbiota are associated...
3.
Kim J, Park S, Kwak C, Lee Y, Song D, Jung J, et al.
Cancer Commun (Lond) . 2023 Dec; 44(1):47-75. PMID: 38133457
Background: Transmembrane 4 L six family member 5 (TM4SF5) translocates subcellularly and functions metabolically, although it is unclear how intracellular TM4SF5 translocation is linked to metabolic contexts. It is thus...
4.
Pinanga Y, Lee H, Shin E, Lee H, Pyo K, Kim J, et al.
iScience . 2023 Sep; 26(9):107625. PMID: 37670786
Transmembrane 4 L six family member 5 (TM4SF5) engages in non-alcoholic steatohepatitis (NASH), although its mechanistic roles are unclear. Genetically engineered mice fed normal chow or high-fat diet for either...
5.
Lee J, Kim E, Kang M, Ryu J, Kim J, Shin E, et al.
BMB Rep . 2022 Sep; 55(12):609-614. PMID: 36104259
Mutation of the gene for adenomatous polyposis coli (APC), as seen in Apc mice, leads to intestinal adenomas and carcinomas via stabilization of β-catenin. Transmembrane 4 L six family member...
6.
Jung J, Kim J, Kim E, Lee H, Lee H, Shin E, et al.
J Extracell Vesicles . 2022 Sep; 11(9):e12262. PMID: 36063136
Transmembrane 4 L six family member 5 (TM4SF5) is involved in chronic liver disease, although its role in glucose homeostasis remains unknown. TM4SF5 deficiency caused age-dependent glucose (in)tolerance with no...
7.
Ko D, Kim E, Shin E, Nam S, Yoon J, Lee J, et al.
Mol Ther Oncolytics . 2022 Feb; 24:452-466. PMID: 35211652
The transmembrane 4 L six family member 5 (TM4SF5) is aberrantly expressed in hepatocellular and colorectal cancers, and has been implicated in tumor progression, suggesting that it could serve as...
8.
Lee H, Kim E, Shin E, Shon J, Sun H, Kim J, et al.
Mol Metab . 2022 Feb; 58:101451. PMID: 35123128
Objective: Transmembrane 4 L six family member 5 (TM4SF5) is likely involved in non-alcoholic steatohepatitis, although its roles and cross-talks with glucose/fructose transporters in phenotypes derived from high-carbohydrate diets remain...
9.
Sun H, Kim E, Ryu J, Lee H, Shin E, Lee M, et al.
Cell Mol Life Sci . 2021 Dec; 79(1):49. PMID: 34921636
Aberrant extracellular matrix and immune cell alterations within the tumor microenvironment promote the pathological progression of liver carcinogenesis. Although transmembrane 4 L six family member 5 (TM4SF5) is involved in...
10.
Kim E, Um H, Park J, Jung J, Kim J, Lee H, et al.
Cell Rep . 2021 Nov; 37(7):110018. PMID: 34788612
Chronic injury to hepatocytes results in inflammation, steatohepatitis, fibrosis, and nonalcoholic fatty liver disease (NAFLD). The tetraspanin TM4SF5 is implicated in fibrosis and cancer. We investigate the role of TM4SF5...