Eugene L Asahchop
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Explore the profile of Eugene L Asahchop including associated specialties, affiliations and a list of published articles.
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21
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443
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Recent Articles
1.
Massanett Aparicio J, Xu Y, Li Y, Colantuoni C, Dastgheyb R, Williams D, et al.
AIDS
. 2021 Jun;
35(11):1795-1804.
PMID: 34074816
Objective: Cognitive impairment remains common in people with HIV (PWH) on antiretroviral therapy (ART). The clinical presentation and severity are highly variable in PWH suggesting that the pathophysiological mechanisms of...
2.
HIV-associated sensory polyneuropathy and neuronal injury are associated with miRNA-455-3p induction
Asahchop E, Branton W, Krishnan A, Chen P, Yang D, Kong L, et al.
JCI Insight
. 2018 Dec;
3(23).
PMID: 30518697
Symptomatic distal sensory polyneuropathy (sDSP) is common and debilitating in people with HIV/AIDS, leading to neuropathic pain, although the condition's cause is unknown. To investigate biomarkers and associated pathogenic mechanisms...
3.
Asahchop E, Meziane O, Mamik M, Chan W, Branton W, Resch L, et al.
Retrovirology
. 2017 Oct;
14(1):47.
PMID: 29037245
Background: In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrophages...
4.
Xu Z, Asahchop E, Branton W, Gelman B, Power C, Hobman T
PLoS Pathog
. 2017 Jun;
13(6):e1006360.
PMID: 28594894
HIV-associated neurocognitive disorders (HAND) represent a spectrum neurological syndrome that affects up to 25% of patients with HIV/AIDS. Multiple pathogenic mechanisms contribute to the development of HAND symptoms including chronic...
5.
Roda W, Li M, Akinwumi M, Asahchop E, Gelman B, Witwer K, et al.
J Neurovirol
. 2017 May;
23(4):577-586.
PMID: 28512685
Understanding HIV-1 replication and latency in different reservoirs is an ongoing challenge in the care of patients with HIV/AIDS. A mathematical model was created to describe and predict the viral...
6.
Mamik M, Asahchop E, Chan W, Zhu Y, Branton W, McKenzie B, et al.
J Neurosci
. 2016 Oct;
36(41):10683-10695.
PMID: 27733618
Significance Statement: HIV-associated neurocognitive disorders (HAND) represent a spectrum disorder of neurocognitive dysfunctions resulting from HIV-1 infection. Although the exact mechanisms causing HAND are unknown, productive HIV-1 infection in the...
7.
Asahchop E, Akinwumi S, Branton W, Fujiwara E, Gill M, Power C
AIDS
. 2016 May;
30(13):2021-31.
PMID: 27191977
Objective: HIV-associated neurocognitive disorder (HAND) is a common neurological disorder among HIV-infected patients despite the availability of combination antiretroviral therapy. Host-encoded microRNAs (miRNA) regulate both host and viral gene expression...
8.
Vivithanaporn P, Asahchop E, Acharjee S, Baker G, Power C
AIDS
. 2015 Nov;
30(4):543-52.
PMID: 26558720
Objective: The neurotoxic actions of the HIV protease inhibitors, amprenavir (APV) and lopinavir (LPV) were investigated. Design: With combination antiretroviral therapy (cART), HIV-infected persons exhibit neurocognitive impairments, raising the possibility...
9.
McCallum M, Oliveira M, Ibanescu R, Kramer V, Moisi D, Asahchop E, et al.
Antimicrob Agents Chemother
. 2013 Jul;
57(10):4681-8.
PMID: 23856772
E138K, a G→A mutation in HIV-1 reverse transcriptase (RT), is preferentially selected by etravirine (ETR) and rilpivirine over other substitutions at position E138 that offer greater drug resistance. We hypothesized...
10.
Xu H, Colby-Germinario S, Asahchop E, Oliveira M, McCallum M, Schader S, et al.
Antimicrob Agents Chemother
. 2013 Apr;
57(7):3100-9.
PMID: 23612196
Impacts of mutations at position E138 (A/G/K/Q/R/V) alone or in combination with M184I in HIV-1 reverse transcriptase (RT) were investigated. We also determined why E138K is the most prevalent nonnucleoside...