Eugene Khandros
Overview
Explore the profile of Eugene Khandros including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
818
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Recent Articles
1.
Khandros E, Blobel G
Blood
. 2024 May;
144(8):845-852.
PMID: 38728575
It has been known for over half a century that throughout ontogeny, humans produce different forms of hemoglobin, a tetramer of α- and β-like hemoglobin chains. The switch from fetal...
2.
Lechauve C, Keith J, Dudley M, Fernandez A, Khandros E, Mayberry K, et al.
Blood Adv
. 2024 Mar;
8(23):5988-5992.
PMID: 38536944
No abstract available.
3.
Huang P, Peslak S, Shehu V, Keller C, Giardine B, Shi J, et al.
Blood
. 2024 Feb;
143(19):1980-1991.
PMID: 38364109
The switch from fetal hemoglobin (γ-globin, HBG) to adult hemoglobin (β-globin, HBB) gene transcription in erythroid cells serves as a paradigm for a complex and clinically relevant developmental gene regulatory...
4.
Huang P, Peslak S, Ren R, Khandros E, Qin K, Keller C, et al.
Nat Genet
. 2023 Jul;
55(9):1608.
PMID: 37524792
No abstract available.
5.
Qin K, Lan X, Huang P, Saari M, Khandros E, Keller C, et al.
Blood
. 2023 Mar;
141(22):2756-2770.
PMID: 36893455
The switch from fetal hemoglobin (HbF) to adult hemoglobin (HbA) is a paradigm for developmental gene expression control with relevance to sickle cell disease and β-thalassemia. Polycomb repressive complex (PRC)...
6.
Vermunt M, Luan J, Zhang Z, Thrasher A, Huang A, Saari M, et al.
Mol Cell
. 2023 Mar;
83(5):715-730.e6.
PMID: 36868189
Transcriptional enhancers have been extensively characterized, but cis-regulatory elements involved in acute gene repression have received less attention. Transcription factor GATA1 promotes erythroid differentiation by activating and repressing distinct gene...
7.
Huang P, Peslak S, Ren R, Khandros E, Qin K, Keller C, et al.
Nat Genet
. 2022 Aug;
54(9):1417-1426.
PMID: 35941187
The fetal-to-adult switch in hemoglobin production is a model of developmental gene control with relevance to the treatment of hemoglobinopathies. The expression of transcription factor BCL11A, which represses fetal β-type...
8.
Qin K, Huang P, Feng R, Keller C, Peslak S, Khandros E, et al.
Nat Genet
. 2022 Jun;
54(6):906.
PMID: 35650318
No abstract available.
9.
Wakabayashi A, Kihiu M, Sharma M, Thrasher A, Saari M, Quesnel-Vallieres M, et al.
Blood Adv
. 2022 May;
6(23):5956-5968.
PMID: 35622975
The fetal-to-adult hemoglobin transition is clinically relevant because reactivation of fetal hemoglobin (HbF) significantly reduces morbidity and mortality associated with sickle cell disease (SCD) and β-thalassemia. Most studies on the...
10.
Qin K, Huang P, Feng R, Keller C, Peslak S, Khandros E, et al.
Nat Genet
. 2022 May;
54(6):874-884.
PMID: 35618846
The mechanisms by which the fetal-type β-globin-like genes HBG1 and HBG2 are silenced in adult erythroid precursor cells remain a fundamental question in human biology and have therapeutic relevance to...