Eugene C Chen
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Explore the profile of Eugene C Chen including associated specialties, affiliations and a list of published articles.
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13
Citations
360
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Recent Articles
1.
Kang S, Chen E, Cifuentes H, Co J, Cole G, Graham J, et al.
Biofabrication
. 2024 Aug;
16(4).
PMID: 39189069
Recent years have seen the creation and popularization of various complexmodels (CIVMs), such as organoids and organs-on-chip, as a technology with the potential to reduce animal usage in pharma while...
2.
Zhang D, Ma B, Dragovich P, Ma L, Chen S, Chen E, et al.
Commun Med (Lond)
. 2024 May;
4(1):87.
PMID: 38755248
Background: Proteolysis-targeting chimeras (PROTACs) are being developed for therapeutic use. However, they have poor pharmacokinetic profiles and their tissue distribution kinetics are not known. Methods: A typical von Hippel-Lindau tumor...
3.
Giacomini K, Yee S, Koleske M, Zou L, Matsson P, Chen E, et al.
Clin Pharmacol Ther
. 2022 Apr;
112(3):540-561.
PMID: 35488474
Enabled by a plethora of new technologies, research in membrane transporters has exploded in the past decade. The goal of this state-of-the-art article is to describe recent advances in research...
4.
Chen E, Matsson P, Azimi M, Zhou X, Handin N, Yee S, et al.
Pharm Res
. 2022 Jan;
39(7):1599-1613.
PMID: 35089508
Introduction: The organic cation transporter 3 (OCT3, SLC22A3) is ubiquitously expressed and interacts with a wide array of compounds including endogenous molecules, environmental toxins and prescription drugs. Understudied as a...
5.
Lombana T, Rajan S, Zorn J, Mandikian D, Chen E, Estevez A, et al.
MAbs
. 2019 May;
11(6):1122-1138.
PMID: 31122132
IgA antibodies have broad potential as a novel therapeutic platform based on their superior receptor-mediated cytotoxic activity, potent neutralization of pathogens, and ability to transcytose across mucosal barriers via polymeric...
6.
Chen Y, Zhu R, Ma F, Mao J, Chen E, Choo E, et al.
Biopharm Drug Dispos
. 2018 Oct;
39(9):420-430.
PMID: 30335192
GDC-0810 was under development as an oral anti-cancer drug for the treatment of estrogen receptor-positive breast cancer as a single agent or in combination. In vitro data indicated that GDC-0810...
7.
Chen E, Broccatelli F, Plise E, Chen B, Liu L, Cheong J, et al.
Mol Pharm
. 2018 Sep;
15(11):5103-5113.
PMID: 30222362
Permeability assays are commonly conducted with Madin-Darby canine kidney (MDCK) cells to predict the intestinal absorption of small-molecule drug candidates. In addition, MDCK cells transfected to overexpress efflux transporters are...
8.
Liang X, Yee S, Chien H, Chen E, Luo Q, Zou L, et al.
PLoS Biol
. 2018 Apr;
16(4):e2002907.
PMID: 29659562
A constellation of metabolic disorders, including obesity, dysregulated lipids, and elevations in blood glucose levels, has been associated with cardiovascular disease and diabetes. Analysis of data from recently published genome-wide...
9.
Chen E, Khuri N, Liang X, Stecula A, Chien H, Yee S, et al.
J Med Chem
. 2017 Feb;
60(7):2685-2696.
PMID: 28230985
Organic cation transporter 1 (OCT1) plays a critical role in the hepatocellular uptake of structurally diverse endogenous compounds and xenobiotics. Here we identified competitive and noncompetitive OCT1-interacting ligands in a...
10.
Liang X, Chien H, Yee S, Giacomini M, Chen E, Piao M, et al.
Mol Pharm
. 2015 Nov;
12(12):4301-10.
PMID: 26528626
The biguanide metformin is widely used as first-line therapy for the treatment of type 2 diabetes. Predominately a cation at physiological pH's, metformin is transported by membrane transporters, which play...