Esther Sleddens-Linkels
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Explore the profile of Esther Sleddens-Linkels including associated specialties, affiliations and a list of published articles.
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15
Citations
389
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Recent Articles
1.
Key J, Gispert S, Koornneef L, Sleddens-Linkels E, Kohli A, Torres-Odio S, et al.
Cells
. 2023 Jan;
12(1).
PMID: 36611846
Human Perrault syndrome (PRLTS) is autosomal, recessively inherited, and characterized by ovarian insufficiency with hearing loss. Among the genetic causes are mutations of matrix peptidase CLPP, which trigger additional azoospermia....
2.
Koornneef L, Slotman J, Sleddens-Linkels E, van Cappellen W, Barchi M, Toth A, et al.
PLoS Genet
. 2022 Jul;
18(7):e1010046.
PMID: 35857787
Recombinases RAD51 and its meiosis-specific paralog DMC1 accumulate on single-stranded DNA (ssDNA) of programmed DNA double strand breaks (DSBs) in meiosis. Here we used three-color dSTORM microscopy, and a mouse...
3.
Ghouil R, Miron S, Koornneef L, Veerman J, Paul M, Le Du M, et al.
Nat Commun
. 2021 Jul;
12(1):4605.
PMID: 34326328
BRCA2 and its interactors are required for meiotic homologous recombination (HR) and fertility. Loss of HSF2BP, a BRCA2 interactor, disrupts HR during spermatogenesis. We test the model postulating that HSF2BP...
4.
Enguita-Marruedo A, Sleddens-Linkels E, Ooms M, de Geus V, Wilke M, Blom E, et al.
Fertil Steril
. 2019 Nov;
112(6):1059-1070.e3.
PMID: 31767154
Objective: To establish which meiotic checkpoints are activated in males with severe spermatogenic impairment to improve phenotypic characterization of meiotic defects. Design: Retrospective observational study. Setting: University medical center research...
5.
Magaraki A, Loda A, Gontan C, Merzouk S, Sleddens-Linkels E, Meek S, et al.
Sci Rep
. 2019 Apr;
9(1):6068.
PMID: 30988473
X chromosome inactivation (XCI) is a mammalian specific, developmentally regulated process relying on several mechanisms including antisense transcription, non-coding RNA-mediated silencing, and recruitment of chromatin remodeling complexes. In vitro modeling...
6.
Carofiglio F, Sleddens-Linkels E, Wassenaar E, Inagaki A, van Cappellen W, Grootegoed J, et al.
DNA Repair (Amst)
. 2018 Feb;
63:25-38.
PMID: 29414051
Repair of SPO11-dependent DNA double-strand breaks (DSBs) via homologous recombination (HR) is essential for stable homologous chromosome pairing and synapsis during meiotic prophase. Here, we induced radiation-induced DSBs to study...
7.
Magaraki A, van der Heijden G, Sleddens-Linkels E, Magarakis L, van Cappellen W, Peters A, et al.
Epigenetics Chromatin
. 2017 Mar;
10:11.
PMID: 28293300
Background: In the nuclei of most mammalian cells, pericentric heterochromatin is characterized by DNA methylation, histone modifications such as H3K9me3 and H4K20me3, and specific binding proteins like heterochromatin-binding protein 1...
8.
Mulugeta E, Wassenaar E, Sleddens-Linkels E, van IJcken W, Heard E, Grootegoed J, et al.
Genome Res
. 2016 Aug;
26(9):1202-10.
PMID: 27510564
The X and Y sex chromosomes of placental mammals show hallmarks of a tumultuous evolutionary past. The X Chromosome has a rich and conserved gene content, while the Y Chromosome...
9.
Carofiglio F, Inagaki A, De Vries S, Wassenaar E, Schoenmakers S, Vermeulen C, et al.
PLoS Genet
. 2013 Jun;
9(6):e1003538.
PMID: 23754961
In mammalian meiotic prophase, the initial steps in repair of SPO11-induced DNA double-strand breaks (DSBs) are required to obtain stable homologous chromosome pairing and synapsis. The X and Y chromosomes...
10.
Inagaki A, Sleddens-Linkels E, van Cappellen W, Hibbert R, Sixma T, Hoeijmakers J, et al.
PLoS One
. 2011 Aug;
6(8):e23155.
PMID: 21858012
RAD18 is an ubiquitin ligase involved in replicative damage bypass and DNA double-strand break (DSB) repair processes. We found that RPA is required for the dynamic pattern of RAD18 localization...