Esther C H Uijttewaal
Overview
Explore the profile of Esther C H Uijttewaal including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
7
Citations
94
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Wolf G, Craigon C, Teoh S, Essletzbichler P, Onstein S, Cassidy D, et al.
Cell Chem Biol
. 2025 Jan;
32(2):291-306.e6.
PMID: 39755121
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting "undruggable"...
2.
Uijttewaal E, Lee J, Sell A, Botay N, Vainorius G, Novatchkova M, et al.
Nat Biotechnol
. 2024 Dec;
PMID: 39681701
Pooled genetic screening with CRISPR-Cas9 has enabled genome-wide, high-resolution mapping of genes to phenotypes, but assessing the effect of a given genetic perturbation requires evaluation of each single guide RNA...
3.
Butz S, Schmolka N, Karemaker I, Villasenor R, Schwarz I, Domcke S, et al.
Nat Genet
. 2022 Nov;
54(11):1702-1710.
PMID: 36333500
Genomic imprinting is regulated by parental-specific DNA methylation of imprinting control regions (ICRs). Despite an identical DNA sequence, ICRs can exist in two distinct epigenetic states that are memorized throughout...
4.
Lopes R, Sprouffske K, Sheng C, Uijttewaal E, Wesdorp A, Dahinden J, et al.
Sci Adv
. 2021 Jul;
7(27).
PMID: 34215580
Millions of putative transcriptional regulatory elements (TREs) have been cataloged in the human genome, yet their functional relevance in specific pathophysiological settings remains to be determined. This is critical to...
5.
Vos E, Valdes-Quezada C, Huang Y, Allahyar A, Verstegen M, Felder A, et al.
Mol Cell
. 2021 Jul;
81(15):3082-3095.e6.
PMID: 34197738
To understand how chromatin domains coordinate gene expression, we dissected select genetic elements organizing topology and transcription around the Prdm14 super enhancer in mouse embryonic stem cells. Taking advantage of...
6.
de Wolf B, Oghabian A, Akinyi M, Hanks S, Tromer E, van Hooff J, et al.
EMBO J
. 2021 May;
40(14):e106536.
PMID: 34009673
Aneuploidy is the leading cause of miscarriage and congenital birth defects, and a hallmark of cancer. Despite this strong association with human disease, the genetic causes of aneuploidy remain largely...
7.
Chylinski K, Hubmann M, Hanna R, Yanchus C, Michlits G, Uijttewaal E, et al.
Nat Commun
. 2019 Dec;
10(1):5454.
PMID: 31784531
CRISPR-Cas9 is an efficient and versatile tool for genome engineering in many species. However, inducible CRISPR-Cas9 editing systems that regulate Cas9 activity or sgRNA expression often suffer from significant limitations,...