Esmee P Hoefsmit
Overview
Explore the profile of Esmee P Hoefsmit including associated specialties, affiliations and a list of published articles.
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10
Citations
230
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Recent Articles
1.
Rozeman E, Versluis J, Sikorska K, Hoefsmit E, Dimitriadis P, Rao D, et al.
J Immunother Cancer
. 2023 Jul;
11(7).
PMID: 37479483
Background: Continuous combination of MAPK pathway inhibition (MAPKi) and anti-programmed death-(ligand) 1 (PD-(L)1) showed high response rates, but only limited improvement in progression-free survival (PFS) at the cost of a...
2.
Hoefsmit E, Vollmy F, Rozeman E, Reijers I, Versluis J, Hoekman L, et al.
Cancer Res Commun
. 2023 Apr;
3(4):672-683.
PMID: 37089863
Significance: LRG1 could serve as a potential target and as a biomarker to identify patients with high risk for disease recurrence, and consequently benefit from additional therapies and intensive follow-up.
3.
Rao D, Stunnenberg J, Lacroix R, Dimitriadis P, Kaplon J, Verburg F, et al.
Eur J Immunol
. 2023 Feb;
53(6):e2250258.
PMID: 36788428
Glucose limitation and increased lactic acid levels are consequences of the elevated glycolytic activity of tumor cells, and constitute a metabolic barrier for the function of tumor infiltrating effector immune...
4.
Hoefsmit E, van Royen P, Rao D, Stunnenberg J, Dimitriadis P, Lieftink C, et al.
Cancer Immunol Res
. 2023 Feb;
11(4):450-465.
PMID: 36753604
Cross-presentation of tumor antigens by dendritic cells (DC) is crucial to prime, stimulate and restimulate CD8+ T cells. This process is important in initiating and maintaining an antitumor response. Here,...
5.
Fessenden T, Stopfer L, Chatterjee F, Zulueta J, Mesfin J, Cordero Dumit T, et al.
J Immunother Cancer
. 2022 Jul;
10(7).
PMID: 35820727
Background: For effective tumor elimination, cytotoxic CD8 T cells must recognize tumor-derived antigens presented on class I major histocompatibility complex (MHC-I). Despite a general association between the expression of immunogenic...
6.
Zhang Z, Kong X, Ligtenberg M, van Hal-van Veen S, Visser N, de Bruijn B, et al.
Cell Rep Med
. 2022 Jun;
3(6):100655.
PMID: 35688159
Tumor escape mechanisms for immunotherapy include deficiencies in antigen presentation, diminishing adaptive CD8 T cell antitumor activity. Although innate natural killer (NK) cells are triggered by loss of MHC class...
7.
Hoefsmit E, Rozeman E, Van T, Dimitriadis P, Krijgsman O, Conway J, et al.
J Immunother Cancer
. 2020 Dec;
8(2).
PMID: 33262254
Background: The profound disparity in response to immune checkpoint blockade (ICB) by cutaneous melanoma (CM) and uveal melanoma (UM) patients is not well understood. Therefore, we characterized metastases of CM...
8.
Hoefsmit E, Rozeman E, Haanen J, Blank C
ESMO Open
. 2019 Aug;
4(4):e000472.
PMID: 31423333
Unprecedented successes regarding cancer immunotherapy have been achieved, in which therapeutic agents are used to target immune cells rather than cancer cells. The most effective immunotherapy to date is the...
9.
ODonnell J, Hoefsmit E, Smyth M, Blank C, Teng M
Clin Cancer Res
. 2019 May;
25(19):5743-5751.
PMID: 31040150
Cancer immunotherapies utilizing immune checkpoint inhibitors (ICI) have demonstrated durable efficacy in a proportion of patients with advanced/metastatic cancers. More recently, the use of ICIs for the adjuvant treatment of...
10.
Sabogal Pineros Y, Bal S, Dijkhuis A, Majoor C, Dierdorp B, Dekker T, et al.
Allergy
. 2019 Apr;
74(10):1898-1909.
PMID: 30934128
Background: Activated eosinophils cause major pathology in stable and exacerbating asthma; however, they can also display protective properties like an extracellular antiviral activity. Initial murine studies led us to further...