Ernst R Werner
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Explore the profile of Ernst R Werner including associated specialties, affiliations and a list of published articles.
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75
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2139
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Recent Articles
1.
Kummer D, Dorigatti I, Dunzendorfer-Matt T, Golderer G, Werner E, Watschinger K
J Lipid Res
. 2025 Mar;
:100766.
PMID: 40024572
Plasmalogens are an abundant class of glycerophospholipids with a characteristic 1-O-alk-1'-enyl double bond. While their synthesis has been extensively investigated, their degradation remains understudied. Plasmalogen deficiencies are associated with severe...
2.
Lackner K, Sailer S, van Klinken J, Wever E, Pras-Raves M, Dane A, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2023 Jan;
1868(4):159285.
PMID: 36690320
Alkylglycerol monooxygenase (AGMO) and plasmanylethanolamine desaturase (PEDS1) are enzymes involved in ether lipid metabolism. While AGMO degrades plasmanyl lipids by oxidative cleavage of the ether bond, PEDS1 exclusively synthesizes a...
3.
Werner E, Swinkels D, Juric V, Dorninger F, Baes M, Keller M, et al.
Brain Res Bull
. 2022 Dec;
193:158-165.
PMID: 36584717
On the basis of findings that cultured rat hepatocytes secrete lipoprotein with a high plasmalogen content and the occurrence of this lipid in human serum, it has been suggested that...
4.
Dorninger F, Werner E, Berger J, Watschinger K
Front Cell Dev Biol
. 2022 Sep;
10:946393.
PMID: 36120579
Due to their unique chemical structure, plasmalogens do not only exhibit distinct biophysical and biochemical features, but require specialized pathways of biosynthesis and metabolization. Recently, major advances have been made...
5.
Koch J, Watschinger K, Werner E, Keller M
Front Cell Dev Biol
. 2022 May;
10:864716.
PMID: 35573699
Typically, glycerophospholipids are represented with two esterified fatty acids. However, by up to 20%, a significant proportion of this lipid class carries an ether-linked fatty alcohol side chain at the...
6.
Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown
Sailer S, Lackner K, Pras-Raves M, Wever E, van Klinken J, Dane A, et al.
J Lipid Res
. 2022 May;
63(6):100222.
PMID: 35537527
Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids. Expression and enzymatic activity of this...
7.
Werner E, Fernandez-Quintero M, Hulo N, Golderer G, Sailer S, Lackner K, et al.
Cell Mol Life Sci
. 2022 Mar;
79(4):214.
PMID: 35347434
Plasmalogens are an abundant class of glycerophospholipids in the mammalian body, with special occurrence in the brain and in immune cell membranes. Plasmanylethanolamine desaturase (PEDS1) is the final enzyme of...
8.
Lopez-Berges M, Scheven M, Hortschansky P, Misslinger M, Baldin C, Gsaller F, et al.
Int J Mol Sci
. 2021 Jul;
22(14).
PMID: 34299357
The airborne fungus causes opportunistic infections in humans with high mortality rates in immunocompromised patients. Previous work established that the bZIP transcription factor HapX is essential for virulence via adaptation...
9.
Fischer C, Wilken-Schmitz A, Hernandez-Olmos V, Proschak E, Stark H, Fleming I, et al.
Cells
. 2021 Jun;
10(5).
PMID: 34062826
Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids. The present study describes the disclosure and...
10.
Schmitz K, Trautmann S, Hahnefeld L, Fischer C, Schreiber Y, Wilken-Schmitz A, et al.
Neurotherapeutics
. 2021 Apr;
18(3):1862-1879.
PMID: 33844153
Depletion of the enzyme cofactor, tetrahydrobiopterin (BH4), in T-cells was shown to prevent their proliferation upon receptor stimulation in models of allergic inflammation in mice, suggesting that BH4 drives autoimmunity....