Ermira Samara-Kuko
Overview
Explore the profile of Ermira Samara-Kuko including associated specialties, affiliations and a list of published articles.
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10
Citations
744
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Recent Articles
1.
Tipanee J, Samara-Kuko E, Gevaert T, Chuah M, VandenDriessche T
Mol Ther
. 2022 Jun;
30(10):3155-3175.
PMID: 35711141
Allogeneic CD19-specific chimeric antigen receptor (CAR) T cells with inactivated donor T cell receptor (TCR) expression can be used as an "off-the-shelf" therapeutic modality for lymphoid malignancies, thus offering an...
2.
Nair N, De Wolf D, Nguyen P, Pham Q, Samara-Kuko E, Landau J, et al.
Blood
. 2021 Mar;
137(21):2902-2906.
PMID: 33735915
Sustained expression of therapeutic factor IX (FIX) levels has been achieved after adeno-associated viral (AAV) vector-based gene therapy in patients with hemophilia B. Nevertheless, patients are still at risk of...
3.
Tipanee J, Di Matteo M, Tulalamba W, Samara-Kuko E, Keirsse J, Van Ginderachter J, et al.
Mol Ther Nucleic Acids
. 2020 Mar;
19:1309-1329.
PMID: 32160703
We established a semi-high-throughput in vivo screening platform using hyperactive piggyBac (hyPB) transposons (designated as PB-miR) to identify microRNAs (miRs) that inhibit hepatocellular carcinoma (HCC) development in vivo, following miR...
4.
Singh K, Evens H, Nair N, Rincon M, Sarcar S, Samara-Kuko E, et al.
Mol Ther
. 2018 Mar;
26(5):1241-1254.
PMID: 29599079
In vivo tissue-specific genome editing at the desired loci is still a challenge. Here, we report that AAV9-delivery of truncated guide RNAs (gRNAs) and Cas9 under the control of a...
5.
Loperfido M, Jarmin S, Dastidar S, Di Matteo M, Perini I, Moore M, et al.
Nucleic Acids Res
. 2015 Dec;
44(2):744-60.
PMID: 26682797
Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disorder caused by the absence of dystrophin. We developed a novel gene therapy approach based on the use of the piggyBac (PB)...
6.
Rincon M, Sarcar S, Danso-Abeam D, Keyaerts M, Matrai J, Samara-Kuko E, et al.
Mol Ther
. 2014 Sep;
23(1):43-52.
PMID: 25195597
Gene therapy is a promising emerging therapeutic modality for the treatment of cardiovascular diseases and hereditary diseases that afflict the heart. Hence, there is a need to develop robust cardiac-specific...
7.
Chuah M, Petrus I, De Bleser P, Le Guiner C, Gernoux G, Adjali O, et al.
Mol Ther
. 2014 Jun;
22(9):1605-13.
PMID: 24954473
The robustness and safety of liver-directed gene therapy can be substantially improved by enhancing expression of the therapeutic transgene in the liver. To achieve this, we developed a new approach...
8.
Matrai J, Cantore A, Bartholomae C, Annoni A, Wang W, Acosta-Sanchez A, et al.
Hepatology
. 2011 Apr;
53(5):1696-707.
PMID: 21520180
Unlabelled: Lentiviral vectors are attractive tools for liver-directed gene therapy because of their capacity for stable gene expression and the lack of preexisting immunity in most human subjects. However, the...
9.
Belay E, Matrai J, Acosta-Sanchez A, Ma L, Quattrocelli M, Mates L, et al.
Stem Cells
. 2010 Aug;
28(10):1760-71.
PMID: 20715185
Adult stem cells and induced pluripotent stem cells (iPS) hold great promise for regenerative medicine. The development of robust nonviral approaches for stem cell gene transfer would facilitate functional studies...
10.
Mates L, Chuah M, Belay E, Jerchow B, Manoj N, Acosta-Sanchez A, et al.
Nat Genet
. 2009 May;
41(6):753-61.
PMID: 19412179
The Sleeping Beauty (SB) transposon is a promising technology platform for gene transfer in vertebrates; however, its efficiency of gene insertion can be a bottleneck in primary cell types. A...