Erik S Zimmerman
Overview
Explore the profile of Erik S Zimmerman including associated specialties, affiliations and a list of published articles.
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12
Citations
1738
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Recent Articles
1.
Sun B, Maranville J, Peters J, Stacey D, Staley J, Blackshaw J, et al.
Nature
. 2018 Jun;
558(7708):73-79.
PMID: 29875488
Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not...
2.
Stafford R, Zimmerman E, Hallam T, Sato A
J Chem Inf Model
. 2014 Sep;
54(10):3020-32.
PMID: 25243907
Protein engineering projects often amass numerous raw DNA sequences, but no readily available software combines sequence processing and activity correlation required for efficient lead identification. XLibraryDisplay is an open source...
3.
Zimmerman E, Heibeck T, Gill A, Li X, Murray C, Madlansacay M, et al.
Bioconjug Chem
. 2014 Jan;
25(2):351-61.
PMID: 24437342
Antibody-drug conjugates (ADCs) are a targeted chemotherapeutic currently at the cutting edge of oncology medicine. These hybrid molecules consist of a tumor antigen-specific antibody coupled to a chemotherapeutic small molecule....
4.
Duda D, Scott D, Calabrese M, Zimmerman E, Zheng N, Schulman B
Curr Opin Struct Biol
. 2011 Feb;
21(2):257-64.
PMID: 21288713
Cullin-RING ligases (CRLs) compose the largest class of E3 ubiquitin ligases. CRLs are modular, multisubunit enzymes, comprising interchangeable substrate receptors dedicated to particular Cullin-RING catalytic cores. Recent structural studies have...
5.
Zimmerman E, Schulman B, Zheng N
Curr Opin Struct Biol
. 2010 Oct;
20(6):714-21.
PMID: 20880695
The cullin-RING ubiquitin ligases (CRLs) are the largest family of multi-subunit E3 ligases in eukaryotes, which ubiquitinate protein substrates in numerous cellular pathways. CRLs share a common arched scaffold and...
6.
DeHart J, Zimmerman E, Ardon O, Monteiro-Filho C, Arganaraz E, Planelles V
Virol J
. 2007 Jun;
4:57.
PMID: 17559673
HIV-1 Vpr is a viral accessory protein that activates ATR through the induction of DNA replication stress. ATR activation results in cell cycle arrest in G2 and induction of apoptosis....
7.
Andersen J, DeHart J, Zimmerman E, Ardon O, Kim B, Jacquot G, et al.
PLoS Pathog
. 2006 Dec;
2(12):e127.
PMID: 17140287
The HIV-1 accessory protein viral protein R (Vpr) causes G2 arrest and apoptosis in infected cells. We previously identified the DNA damage-signaling protein ATR as the cellular factor that mediates...
8.
Zimmerman E, Sherman M, Blackett J, Neidleman J, Kreis C, Mundt P, et al.
J Virol
. 2006 Sep;
80(21):10407-18.
PMID: 16956949
The human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) causes cell cycle arrest in G2. Vpr-expressing cells display the hallmarks of certain forms of DNA damage, specifically activation...
9.
Ardon O, Zimmerman E, Andersen J, DeHart J, Blackett J, Planelles V
J Virol
. 2006 Mar;
80(8):3694-700.
PMID: 16571786
Cyclophilin A (CypA) is a member of a family of cellular proteins that share a peptidyl prolyl cis-trans isomerase (PPIase) activity. CypA was previously reported to be required for the...
10.
Lai M, Zimmerman E, Planelles V, Chen J
J Virol
. 2005 Nov;
79(24):15443-51.
PMID: 16306615
The human immunodeficiency virus type 1 (HIV-1) protein Vpr (viral protein R) arrests cells in the G2 phase of the cell cycle, a process that requires activation of the ATR...