Erik M Jorgensen
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Explore the profile of Erik M Jorgensen including associated specialties, affiliations and a list of published articles.
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115
Citations
6853
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Recent Articles
1.
Davison C, Garcia D, Feng C, Hao H, Jorgensen E, Hammarlund M
bioRxiv
. 2025 Mar;
PMID: 40060495
Axons experience physical stress throughout an organism's lifetime, and disruptions in axonal integrity are hallmarks of both neurodegenerative diseases and traumatic injuries. The spectrin-based membrane periodic skeleton (MPS) is proposed...
2.
Frankel E, Tiroumalechetty A, Su Z, Henry P, Mueller B, Jorgensen E, et al.
Neuron
. 2025 Jan;
113(5):737-753.e6.
PMID: 39814011
Neurexin cell-adhesion molecules regulate synapse development and function by recruiting synaptic components. Here, we uncover a mechanism for presynaptic assembly that precedes neurexin recruitment, mediated by interactions between cytosolic proteins...
3.
Davis M, Jorgensen E
Methods Mol Biol
. 2024 Oct;
2850():79-87.
PMID: 39363067
Golden Gate cloning allows rapid and reliable assembly of multiple DNA fragments in a defined orientation. Golden Gate cloning requires careful design of the restriction fragment overhangs to minimize undesired...
4.
Mueller B, Merrill S, von Diezmann L, Jorgensen E
Bio Protoc
. 2024 Aug;
14(16):e5049.
PMID: 39210951
Calcium channels at synaptic boutons are critical for synaptic function, but their number and distribution are poorly understood. This gap in knowledge is primarily due to the resolution limits of...
5.
Koopman M, Gungordu L, Janssen L, Seinstra R, Richmond J, Okerlund N, et al.
Cell Rep
. 2024 May;
43(5):114204.
PMID: 38748878
Amyotrophic lateral sclerosis can be caused by abnormal accumulation of TAR DNA-binding protein 43 (TDP-43) in the cytoplasm of neurons. Here, we use a C. elegans model for TDP-43-induced toxicity...
6.
Fernando S, Martineau J, Hobson R, Vu T, Baker B, Mueller B, et al.
Opt Express
. 2023 Oct;
31(20):33565-33581.
PMID: 37859135
By engineering the point-spread function (PSF) of single molecules, different fluorophore species can be imaged simultaneously and distinguished by their unique PSF patterns. Here, we insert a silicon-dioxide phase plate...
7.
Palfreyman M, West S, Jorgensen E
Adv Neurobiol
. 2023 Aug;
33:63-118.
PMID: 37615864
Neurotransmitters are stored in small membrane-bound vesicles at synapses; a subset of synaptic vesicles is docked at release sites. Fusion of docked vesicles with the plasma membrane releases neurotransmitters. Membrane...
8.
Mueller B, Merrill S, Watanabe S, Liu P, Niu L, Singh A, et al.
Elife
. 2023 Feb;
12.
PMID: 36820519
Activation of voltage-gated calcium channels at presynaptic terminals leads to local increases in calcium and the fusion of synaptic vesicles containing neurotransmitter. Presynaptic output is a function of the density...
9.
Davis M, Jorgensen E
Front Bioinform
. 2022 Oct;
2:818619.
PMID: 36304290
A plasmid Editor (ApE) is a free, multi-platform application for visualizing, designing, and presenting biologically relevant DNA sequences. ApE provides a flexible framework for annotating a sequence manually or using...
10.
Imoto Y, Raychaudhuri S, Ma Y, Fenske P, Sandoval E, Itoh K, et al.
Neuron
. 2022 Jul;
110(17):2815-2835.e13.
PMID: 35809574
Dynamin mediates fission of vesicles from the plasma membrane during endocytosis. Typically, dynamin is recruited from the cytosol to endocytic sites, requiring seconds to tens of seconds. However, ultrafast endocytosis...