Erik Lykken
Overview
Explore the profile of Erik Lykken including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
307
Followers
0
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Recent Articles
1.
Kot S, Karumuthil-Melethil S, Woodley E, Zaric V, Thompson P, Chen Z, et al.
Int J Mol Sci
. 2021 Jul;
22(13).
PMID: 34201771
GM2 gangliosidosis disorders are a group of neurodegenerative diseases that result from a functional deficiency of the enzyme β-hexosaminidase A (HexA). HexA consists of an α- and β-subunit; a deficiency...
2.
Xu X, Zhang Y, Jasper J, Lykken E, Alexander P, Markowitz G, et al.
Oncotarget
. 2016 Mar;
7(15):20381-94.
PMID: 26967387
Triple-negative breast cancer (TNBC) presents a major challenge in the clinic due to its lack of reliable prognostic markers and targeted therapies. Accumulating evidence strongly supports the notion that microRNAs...
3.
Zhang B, Liu S, Li C, Lykken E, Jiang S, Wong E, et al.
Immunity
. 2016 Feb;
44(3):568-581.
PMID: 26921109
Upon antigen engagement, augmented cytosolic reactive oxygen species (ROS) are needed to achieve optimal T cell receptor (TCR) signaling. However, uncontrolled ROS production is a prominent cause of necrosis, which...
4.
Li C, Jiang S, Liu S, Lykken E, Zhao L, Sevilla J, et al.
Proc Natl Acad Sci U S A
. 2014 Jun;
111(27):E2807-16.
PMID: 24958888
Forkhead box P3(+) (Foxp3(+)) regulatory T cells (Tregs) are crucial for peripheral tolerance. During inflammation, steady Foxp3 expression in Tregs is essential for maintaining their lineage identity and suppressive function....
5.
Jiang S, Li C, McRae G, Lykken E, Sevilla J, Liu S, et al.
Sci Signal
. 2014 Mar;
7(316):ra25.
PMID: 24619648
Methyl CpG binding protein 2 (MeCP2) is an X-linked, multifunctional epigenetic regulator that is best known for its role in the neurological disorder Rett syndrome; however, it is also linked...
6.
Jiang S, Li C, Olive V, Lykken E, Feng F, Sevilla J, et al.
Blood
. 2011 Oct;
118(20):5487-97.
PMID: 21972292
Mir-17-92 encodes 6 miRNAs inside a single polycistronic transcript, the proper expression of which is critical for early B-cell development and lymphocyte homeostasis. However, during the T-cell antigen response, the...