Erica Ollmann Saphire
Overview
Explore the profile of Erica Ollmann Saphire including associated specialties, affiliations and a list of published articles.
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189
Citations
9926
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Recent Articles
21.
Moreno L, Barreto de Albuquerque J, Neary J, Nguyen T, Hastie K, Landeras-Bueno S, et al.
bioRxiv
. 2023 Nov;
PMID: 38014059
Understanding adaptive immunity against SARS-CoV-2 is a major requisite for the development of effective vaccines and treatments for COVID-19. CD4 T cells play an integral role in this process primarily...
22.
Yu X, Hastie K, Davis C, Avalos R, Williams D, Parekh D, et al.
Cell Rep
. 2023 Nov;
42(11):113366.
PMID: 37938974
Monoclonal antibodies against the Ebola virus (EBOV) surface glycoprotein are effective treatments for EBOV disease. Antibodies targeting the EBOV glycoprotein (GP) head epitope have potent neutralization and Fc effector function...
23.
Streblow D, Hirsch A, Stanton J, Lewis A, Colgin L, Hessell A, et al.
Nat Commun
. 2023 Nov;
14(1):7062.
PMID: 37923717
Passively administered monoclonal antibodies (mAbs) given before or after viral infection can prevent or blunt disease. Here, we examine the efficacy of aerosol mAb delivery to prevent infection and disease...
24.
Hastie K, Melnik L, Cross R, Klitting R, Andersen K, Saphire E, et al.
J Infect Dis
. 2023 Oct;
228(Suppl 6):S359-S375.
PMID: 37849403
Lassa virus (LASV), Junin virus (JUNV), and several other members of the Arenaviridae family are capable of zoonotic transfer to humans and induction of severe viral hemorrhagic fevers. Despite the...
25.
Fang J, Castillon G, Phan S, McArdle S, Hariharan C, Adams A, et al.
Nat Commun
. 2023 Jul;
14(1):4159.
PMID: 37443171
Ebola virus (EBOV) infection induces the formation of membrane-less, cytoplasmic compartments termed viral factories, in which multiple viral proteins gather and coordinate viral transcription, replication, and assembly. Key to viral...
26.
Werner A, Schauflinger M, Norris M, Kluver M, Trodler A, Herwig A, et al.
Structure
. 2023 Jul;
31(9):1038-1051.e7.
PMID: 37392738
The Ebola virus matrix protein VP40 mediates viral budding and negatively regulates viral RNA synthesis. The mechanisms by which these two functions are exerted and regulated are unknown. Using a...
27.
Hastie K, Yu X, Ana-Sosa-Batiz F, Zyla D, Harkins S, Hariharan C, et al.
Cell Rep
. 2023 Apr;
42(5):112421.
PMID: 37083327
Therapeutic antibodies are an important tool in the arsenal against coronavirus infection. However, most antibodies developed early in the pandemic have lost most or all efficacy against newly emergent strains...
28.
Gunn B, McNamara R, Wood L, Taylor S, Devadhasan A, Guo W, et al.
Cell Rep
. 2023 Apr;
42(4):112402.
PMID: 37061918
The 2013 Ebola epidemic in Central and West Africa heralded the emergence of wide-spread, highly pathogenic viruses. The successful recombinant vector vaccine against Ebola (rVSVΔG-ZEBOV-GP) will limit future outbreaks, but...
29.
Killian J, King R, Lucander A, Kizziah J, Fucile C, Diaz-Avalos R, et al.
bioRxiv
. 2023 Apr;
PMID: 37034637
Donor-specific antibody (DSA) responses against human leukocyte antigen (HLA) proteins mismatched between kidney transplant donors and recipients cause allograft loss. The rules governing the immunogenicity of non-self donor HLA are...
30.
Chen E, Gilchuk P, Zost S, Ilinykh P, Binshtein E, Huang K, et al.
Cell Rep
. 2023 Apr;
42(4):112370.
PMID: 37029928
Understanding the human antibody response to emerging viral pathogens is key to epidemic preparedness. As the size of the B cell response to a pathogenic-virus-protective antigen is poorly defined, we...