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Eric R Greene

Explore the profile of Eric R Greene including associated specialties, affiliations and a list of published articles. Areas
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Articles 8
Citations 662
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Recent Articles
1.
Tecson M, Geluz C, Cruz Y, Greene E
Biochemistry . 2025 Jan; 64(3):547-554. PMID: 39844577
Glutamine synthetase (GS) is a ubiquitous enzyme central to nitrogen metabolism, catalyzing the ATP-dependent formation of glutamine from glutamate and ammonia. Positioned at the intersection of nitrogen metabolism with carbon...
2.
Madani A, Krause B, Greene E, Subramanian S, Mohr B, Holton J, et al.
Nat Biotechnol . 2023 Jan; 41(8):1099-1106. PMID: 36702895
Deep-learning language models have shown promise in various biotechnological applications, including protein design and engineering. Here we describe ProGen, a language model that can generate protein sequences with a predictable...
3.
Carroll E, Greene E, Martin A, Marqusee S
Nat Chem Biol . 2020 Jun; 16(8):866-875. PMID: 32483380
Changes in the cellular environment modulate protein energy landscapes to drive important biology, with consequences for signaling, allostery and other vital processes. The effects of ubiquitination are particularly important because...
4.
Greene E, Dong K, Martin A
Curr Opin Struct Biol . 2019 Nov; 61:33-41. PMID: 31783300
The 26S proteasome is the essential compartmental protease in eukaryotic cells required for the ubiquitin-dependent clearance of damaged polypeptides and obsolete regulatory proteins. Recently, a combination of high-resolution structural, biochemical,...
5.
Greene E, Goodall E, H de la Pena A, Matyskiela M, Lander G, Martin A
Elife . 2019 Nov; 8. PMID: 31778111
The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasome's regulatory particle, consisting...
6.
Bard J, Goodall E, Greene E, Jonsson E, Dong K, Martin A
Annu Rev Biochem . 2018 Apr; 87:697-724. PMID: 29652515
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The proteasome's cellular functions range from general...
7.
Guan X, Chaffey P, Zeng C, Greene E, Chen L, Drake M, et al.
Chem Sci . 2017 Oct; 6(12):7185-7189. PMID: 28966766
Protein glycosylation is a ubiquitous post-translational modification in all kingdoms of life. Despite its importance in molecular and cellular biology, the molecular-level ramifications of -glycosylation on biomolecular structure and function...
8.
Greene E, Himmel M, Beckham G, Tan Z
Adv Carbohydr Chem Biochem . 2015 Nov; 72:63-112. PMID: 26613815
Cellulose in plant cell walls is the largest reservoir of renewable carbon on Earth. The saccharification of cellulose from plant biomass into soluble sugars can be achieved using fungal and...
9.
Chen L, Drake M, Resch M, Greene E, Himmel M, Chaffey P, et al.
Proc Natl Acad Sci U S A . 2014 May; 111(21):7612-7. PMID: 24821760
The majority of biological turnover of lignocellulosic biomass in nature is conducted by fungi, which commonly use Family 1 carbohydrate-binding modules (CBMs) for targeting enzymes to cellulose. Family 1 CBMs...