Eric M Feeley
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Explore the profile of Eric M Feeley including associated specialties, affiliations and a list of published articles.
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11
Citations
2326
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Recent Articles
1.
Piro A, Hernandez D, Luoma S, Feeley E, Finethy R, Yirga A, et al.
mBio
. 2017 Dec;
8(6).
PMID: 29233899
Dynamin-like guanylate binding proteins (GBPs) are gamma interferon (IFN-γ)-inducible host defense proteins that can associate with cytosol-invading bacterial pathogens. Mouse GBPs promote the lytic destruction of targeted bacteria in the...
2.
Finethy R, Luoma S, Orench-Rivera N, Feeley E, Haldar A, Yamamoto M, et al.
mBio
. 2017 Oct;
8(5).
PMID: 28974614
The Gram-negative bacterial cell wall component lipopolysaccharide (LPS) is recognized by the noncanonical inflammasome protein caspase-11 in the cytosol of infected host cells and thereby prompts an inflammatory immune response...
3.
Zwack E, Feeley E, Burton A, Hu B, Yamamoto M, Kanneganti T, et al.
Infect Immun
. 2017 Aug;
85(10).
PMID: 28784930
Gram-negative bacterial pathogens utilize virulence-associated secretion systems to inject, or translocate, effector proteins into host cells to manipulate cellular processes and promote bacterial replication. However, translocated bacterial products are sensed...
4.
Feeley E, Pilla-Moffett D, Zwack E, Piro A, Finethy R, Kolb J, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(9):E1698-E1706.
PMID: 28193861
Many invasive bacteria establish pathogen-containing vacuoles (PVs) as intracellular niches for microbial growth. Immunity to these infections is dependent on the ability of host cells to recognize PVs as targets...
5.
Chin C, Perreira J, Savidis G, Portmann J, Aker A, Feeley E, et al.
Cell Rep
. 2015 Nov;
13(8):1717-31.
PMID: 26586435
Direct visualization of HIV-1 replication would improve our understanding of the viral life cycle. We adapted established technology and reagents to develop an imaging approach, ViewHIV, which allows evaluation of...
6.
Haldar A, Foltz C, Finethy R, Piro A, Feeley E, Pilla-Moffett D, et al.
Proc Natl Acad Sci U S A
. 2015 Sep;
112(41):E5628-37.
PMID: 26417105
Many microbes create and maintain pathogen-containing vacuoles (PVs) as an intracellular niche permissive for microbial growth and survival. The destruction of PVs by IFNγ-inducible guanylate binding protein (GBP) and immunity-related...
7.
Perreira J, Chin C, Feeley E, Brass A
J Mol Biol
. 2013 Oct;
425(24):4937-55.
PMID: 24076421
The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus, hepatitis C virus, and Ebola virus. This review covers recent...
8.
John S, Chin C, Perreira J, Feeley E, Aker A, Savidis G, et al.
J Virol
. 2013 May;
87(14):7837-52.
PMID: 23658454
The interferon-induced transmembrane protein 3 (IFITM3) gene is an interferon-stimulated gene that inhibits the replication of multiple pathogenic viruses in vitro and in vivo. IFITM3 is a member of a...
9.
Everitt A, Clare S, Pertel T, John S, Wash R, Smith S, et al.
Nature
. 2012 Mar;
484(7395):519-23.
PMID: 22446628
The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality...
10.
Feeley E, Sims J, John S, Chin C, Pertel T, Chen L, et al.
PLoS Pathog
. 2011 Nov;
7(10):e1002337.
PMID: 22046135
To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication. The...