Eric J Kunkel
Overview
Explore the profile of Eric J Kunkel including associated specialties, affiliations and a list of published articles.
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21
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1380
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Recent Articles
1.
Buckler R, Kunkel E, Thompson M, Ehrhardt R
Cytotherapy
. 2016 Feb;
18(3):301-6.
PMID: 26857225
Despite considerable regulatory and clinical hurdles, the development and use of cell-based therapies are gaining momentum. As more of these therapies move toward commercial approval and larger-scale distribution, associated manufacturing...
2.
Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators
Maifeld S, Mackinnon A, Garrison J, Sharma A, Kunkel E, Hegde R, et al.
Chem Biol
. 2011 Sep;
18(9):1082-8.
PMID: 21944747
Cotransins are cyclic heptadepsipeptides that bind the Sec61 translocon to inhibit cotranslational translocation of a subset of secreted and type I transmembrane proteins. The few known cotransin-sensitive substrates are all...
3.
Williams O, Houseman B, Kunkel E, Aizenstein B, Hoffman R, Knight Z, et al.
Chem Biol
. 2010 Mar;
17(2):123-34.
PMID: 20189103
PI3Kdelta and PI3Kgamma regulate immune cell signaling, while the related PI3Kalpha and PI3Kbeta regulate cell survival and metabolism. Selective inhibitors of PI3Kdelta/gamma represent a potential class of anti-inflammatory agents lacking...
4.
Berg E, Yang J, Melrose J, Nguyen D, Privat S, Rosler E, et al.
J Pharmacol Toxicol Methods
. 2009 Nov;
61(1):3-15.
PMID: 19879948
Introduction: The ability to predict the health effects resulting from drug or chemical exposure has been challenging due to the complexity of human biology. Approaches that detect and discriminate a...
5.
6.
Meier-Schellersheim M, Xu X, Angermann B, Kunkel E, Jin T, Germain R
PLoS Comput Biol
. 2006 Jul;
2(7):e82.
PMID: 16854213
The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential activation/deactivation of membrane-bound and cytosolic components. As such, it provides...
7.
Berg E, Kunkel E, Hytopoulos E, Plavec I
J Pharmacol Toxicol Methods
. 2005 Jul;
53(1):67-74.
PMID: 16040258
Introduction: Unexpected drug activities account for many of the failures of new chemical entities in clinical trials. These activities can be target-dependent, resulting from feedback mechanisms downstream of the primary...
8.
Garrison J, Kunkel E, Hegde R, Taunton J
Nature
. 2005 Jul;
436(7048):285-9.
PMID: 16015336
The segregation of secretory and membrane proteins to the mammalian endoplasmic reticulum is mediated by remarkably diverse signal sequences that have little or no homology with each other. Despite such...
9.
Berg E, Hytopoulos E, Plavec I, Kunkel E
Curr Opin Drug Discov Devel
. 2005 Feb;
8(1):107-14.
PMID: 15679178
The ability to predict the safety and efficacy of novel drugs prior to clinical testing is a key goal in pharmaceutical drug discovery. Gaining a mechanistic understanding of the complex...
10.
Butcher E, Berg E, Kunkel E
Nat Biotechnol
. 2004 Oct;
22(10):1253-9.
PMID: 15470465
The hope of the rapid translation of 'genes to drugs' has foundered on the reality that disease biology is complex, and that drug development must be driven by insights into...