Eric Conway
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Explore the profile of Eric Conway including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
647
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Recent Articles
1.
McCole R, Nolan J, Reck D, Monger C, Rustichelli S, Conway E, et al.
Cell Rep
. 2025 Jan;
44(1):115192.
PMID: 39799569
Polycomb repressive complex 2 (PRC2), composed of the core subunits EED, SUZ12, and either EZH1 or EZH2, is critical for maintaining cellular identity in multicellular organisms. PRC2 deposits H3K27me3, which...
2.
Conway E, Larson D
Curr Opin Struct Biol
. 2024 Dec;
90:102956.
PMID: 39631257
No abstract available.
3.
Davies M, Boyce M, Conway E
Curr Opin Struct Biol
. 2024 Nov;
89:102948.
PMID: 39536500
Core regulatory circuitry refers to the network of lineage-specific transcription factors regulating expression of both their own coding genes, and that of other transcription factors. Such autoregulatory feedback loops coordinate...
4.
Doyle E, Morey L, Conway E
Front Cell Dev Biol
. 2022 Sep;
10:986319.
PMID: 36105358
Chromatin is spatially and temporally regulated through a series of orchestrated processes resulting in the formation of 3D chromatin structures such as topologically associating domains (TADs), loops and Polycomb Bodies....
5.
Tamburri S, Conway E, Pasini D
Trends Genet
. 2021 Aug;
38(4):333-352.
PMID: 34426021
Cell identity is tightly controlled by specific transcriptional programs which require post-translational modifications of histones. These histone modifications allow the establishment and maintenance of active and repressed chromatin domains. Histone...
6.
Conway E, Rossi F, Fernandez-Perez D, Ponzo E, Ferrari K, Zanotti M, et al.
Mol Cell
. 2021 Jun;
81(17):3526-3541.e8.
PMID: 34186021
BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for...
7.
Tamburri S, Lavarone E, Fernandez-Perez D, Conway E, Zanotti M, Manganaro D, et al.
Mol Cell
. 2019 Dec;
77(4):840-856.e5.
PMID: 31883952
Polycomb group proteins (PcGs) maintain transcriptional repression to preserve cellular identity in two distinct repressive complexes, PRC1 and PRC2, that modify histones by depositing H2AK119ub1 and H3K27me3, respectively. PRC1 and...
8.
Healy E, Mucha M, Glancy E, Fitzpatrick D, Conway E, Neikes H, et al.
Mol Cell
. 2019 Sep;
76(3):437-452.e6.
PMID: 31521505
Polycomb repressive complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di-, and trimethylation of histone H3 at lysine 27. At least two independent subcomplexes exist,...
9.
Conway E, Jerman E, Healy E, Ito S, Holoch D, Oliviero G, et al.
Mol Cell
. 2018 Apr;
70(3):408-421.e8.
PMID: 29628311
The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas...
10.
Streubel G, Watson A, Jammula S, Scelfo A, Fitzpatrick D, Oliviero G, et al.
Mol Cell
. 2018 Apr;
70(2):371-379.e5.
PMID: 29606589
The Polycomb repressor complex 2 (PRC2) is composed of the core subunits Ezh1/2, Suz12, and Eed, and it mediates all di- and tri-methylation of histone H3 at lysine 27 in...