En-Zhi Shen
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Explore the profile of En-Zhi Shen including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
370
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0
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Recent Articles
1.
Rao D, Li D, Li L, Xue J, Tu S, Shen E
Nucleic Acids Res
. 2025 Mar;
53(5).
PMID: 40036504
Parental stress can be encoded into altered epigenetic information to influence their offspring. Concurrently, it is vital for the preservation of a parent's epigenetic information, despite environmental challenges, to ensure...
2.
Li Z, Xu Q, Zhong J, Zhang Y, Zhang T, Ying X, et al.
Nature
. 2025 Jan;
639(8053):250-259.
PMID: 39814893
Argonaute proteins are categorized into AGO and PIWI clades. Across most animal species, AGO-clade proteins are widely expressed in various cell types, and regulate normal gene expression. By contrast, PIWI-clade...
3.
Li Z, Li Z, Zhang Y, Zhou L, Xu Q, Li L, et al.
Nat Struct Mol Biol
. 2024 Apr;
31(8):1222-1231.
PMID: 38658622
The PIWI-interacting RNA (piRNA) pathway is an adaptive defense system wherein piRNAs guide PIWI family Argonaute proteins to recognize and silence ever-evolving selfish genetic elements and ensure genome integrity. Driven...
4.
Lyu X, Deng Y, Huang X, Li Z, Fang G, Yang D, et al.
Cell Res
. 2022 Nov;
32(12):1133.
PMID: 36376418
No abstract available.
5.
Lyu X, Deng Y, Huang X, Li Z, Fang G, Yang D, et al.
Cell Res
. 2022 Sep;
32(11):969-981.
PMID: 36104507
The dynamic three-dimensional structures of chromatin and extrachromosomal DNA molecules regulate fundamental cellular processes and beyond. However, the visualization of specific DNA sequences in live cells, especially nonrepetitive sequences accounting...
6.
Dai S, Tang X, Li L, Ishidate T, Ozturk A, Chen H, et al.
Cell Rep
. 2022 Sep;
40(10):111265.
PMID: 36070689
Germline Argonautes direct transcriptome surveillance within perinuclear membraneless organelles called nuage. In C. elegans, a family of Vasa-related Germ Line Helicase (GLH) proteins localize in and promote the formation of...
7.
Li Z, Tang X, Shen E
Signal Transduct Target Ther
. 2020 Sep;
5(1):190.
PMID: 32895365
No abstract available.
8.
Ishidate T, Ozturk A, Durning D, Sharma R, Shen E, Chen H, et al.
Mol Cell
. 2018 May;
70(4):639-649.e6.
PMID: 29775580
Animal cells have a remarkable capacity to adopt durable and heritable gene expression programs or epigenetic states that define the physical properties and diversity of somatic cell types. The maintenance...
9.
Tang W, Seth M, Tu S, Shen E, Li Q, Shirayama M, et al.
Dev Cell
. 2018 Feb;
44(6):762-770.e3.
PMID: 29456136
In metazoans, Piwi-related Argonaute proteins engage piRNAs (Piwi-interacting small RNAs) to defend the genome against invasive nucleic acids, such as transposable elements. Yet many organisms-including worms and humans-express thousands of...
10.
Seth M, Shirayama M, Tang W, Shen E, Tu S, Lee H, et al.
Cell Rep
. 2018 Feb;
22(9):2254-2264.
PMID: 29456100
Protein-coding genes undergo a wide array of regulatory interactions with factors that engage non-coding regions. Open reading frames (ORFs), in contrast, are thought to be constrained by coding function, precluding...