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Emma E Davenport

Explore the profile of Emma E Davenport including associated specialties, affiliations and a list of published articles. Areas
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Articles 29
Citations 1426
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Recent Articles
1.
Tokolyi A, Persyn E, Nath A, Burnham K, Marten J, Vanderstichele T, et al.
Nat Genet . 2025 Mar; 57(3):616-625. PMID: 40038547
The biological mechanisms through which most nonprotein-coding genetic variants affect disease risk are unknown. To investigate gene-regulatory mechanisms, we mapped blood gene expression and splicing quantitative trait loci (QTLs) through...
2.
Sims M, Gierula M, Stephens J, Tokolyi A, Stefanucci L, Persyn E, et al.
Blood Adv . 2024 Oct; 9(1):132-142. PMID: 39365993
The G haplotype is a group of co-inherited single nucleotide variants in the F5 gene that reduce venous thromboembolism (VTE) risk. Although 7% of the population is homozygous for the...
3.
Vanderstichele T, Burnham K, de Klein N, Tardaguila M, Howell B, Walter K, et al.
Am J Hum Genet . 2024 Jul; 111(8):1524-1543. PMID: 39053458
Gene misexpression is the aberrant transcription of a gene in a context where it is usually inactive. Despite its known pathological consequences in specific rare diseases, we have a limited...
4.
Burnham K, Milind N, Lee W, Kwok A, Cano-Gamez K, Mi Y, et al.
Cell Genom . 2024 Jun; 4(7):100587. PMID: 38897207
Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection, for which disease heterogeneity is a major obstacle to developing targeted treatments. We have...
5.
Owen N, Williams T, Maguire J, Kuc R, Davenport E, Davenport A
Biosci Rep . 2024 Jun; 44(7). PMID: 38860875
High blood pressure in the portal vein, portal hypertension (PH), is the final common pathway in liver cirrhosis regardless of aetiology. Complications from PH are the major cause of morbidity...
6.
Mi Y, Burnham K, Charles P, Heilig R, Vendrell I, Whalley J, et al.
Sci Transl Med . 2024 Jun; 16(750):eadh0185. PMID: 38838133
Sepsis, the dysregulated host response to infection causing life-threatening organ dysfunction, is a global health challenge requiring better understanding of pathophysiology and new therapeutic approaches. Here, we applied high-throughput tandem...
7.
Antcliffe D, Mi Y, Santhakumaran S, Burnham K, Prevost A, Ward J, et al.
Thorax . 2024 Mar; 79(6):515-523. PMID: 38471792
Rationale: Heterogeneity of the host response within sepsis, acute respiratory distress syndrome (ARDS) and more widely critical illness, limits discovery and targeting of immunomodulatory therapies. Clustering approaches using clinical and...
8.
Angchagun K, Boonklang P, Chomkatekaew C, Pakdeerat S, Wongsuwan G, Amornchai P, et al.
Wellcome Open Res . 2023 Nov; 8:347. PMID: 37928212
Background: Melioidosis is a frequently fatal disease caused by an environmental bacterium . The disease is prevalent in northeast Thailand, particularly among rice field farmers who are at risk of...
9.
Torrance H, Zhang P, Longbottom E, Mi Y, Whalley J, Allcock A, et al.
Ann Surg . 2023 Jul; 279(3):510-520. PMID: 37497667
Objective: To describe immune pathways and gene networks altered following major abdominal surgery and to identify transcriptomic patterns associated with postoperative pneumonia. Background: Nosocomial infections are a major healthcare challenge,...
10.
Kwok A, Allcock A, Ferreira R, Cano-Gamez E, Smee M, Burnham K, et al.
Nat Immunol . 2023 Apr; 24(5):767-779. PMID: 37095375
Sepsis arises from diverse and incompletely understood dysregulated host response processes following infection that leads to life-threatening organ dysfunction. Here we showed that neutrophils and emergency granulopoiesis drove a maladaptive...