Emilia Manko
Overview
Explore the profile of Emilia Manko including associated specialties, affiliations and a list of published articles.
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17
Citations
101
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Recent Articles
1.
Ibrahim A, Mohring F, Manko E, van Schalkwyk D, Phelan J, Nolder D, et al.
Nat Commun
. 2024 Dec;
15(1):10779.
PMID: 39738025
Plasmodium malariae parasites are widely observed across the tropics and sub-tropics. This slow-growing species, known to maintain chronic asymptomatic infections, has been associated with reduced antimalarial susceptibility. We analyse 251 ...
2.
Ngwana-Joseph G, Phelan J, Manko E, Dombrowski J, da Silva Santos S, Suarez-Mutis M, et al.
Nat Commun
. 2024 Dec;
15(1):10771.
PMID: 39738010
Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear....
3.
Gomez-Gonzalez P, Gupta A, Drought L, Patel A, Okombo J, van der Watt M, et al.
Sci Adv
. 2024 Dec;
10(49):eadq1383.
PMID: 39642214
Cyclic nucleotide-dependent phosphodiesterases (PDEs) play essential roles in regulating the malaria parasite life cycle, suggesting that they may be promising antimalarial drug targets. PDE inhibitors are used safely to treat...
4.
Osborne A, Manko E, Waweru H, Kaneko A, Kita K, Campino S, et al.
Sci Rep
. 2024 Aug;
14(1):18051.
PMID: 39103358
East African countries accounted for ~ 10% of all malaria prevalence worldwide in 2022, with an estimated 23.8 million cases and > 53,000 deaths. Despite recent increases in malaria incidence,...
5.
Higgins M, Manko E, Ward D, Phelan J, Nolder D, Sutherland C, et al.
Sci Rep
. 2024 Feb;
14(1):3843.
PMID: 38360879
Despite Plasmodium ovale curtisi (Poc) and wallikeri (Pow) being important human-infecting malaria parasites that are widespread across Africa and Asia, little is known about their genome diversity. Morphologically identical, Poc...
6.
Eccleston R, Manko E, Campino S, Clark T, Furnham N
Elife
. 2023 Dec;
12.
PMID: 38132182
Pathogen evolution of drug resistance often occurs in a stepwise manner via the accumulation of multiple mutations that in combination have a non-additive impact on fitness, a phenomenon known as...
7.
Phelan J, Turkiewicz A, Manko E, Thorpe J, Vanheer L, van de Vegte-Bolmer M, et al.
Genome Med
. 2023 Nov;
15(1):96.
PMID: 37950308
Background: Malaria continues to be a major threat to global public health. Whole genome sequencing (WGS) of the underlying Plasmodium parasites has provided insights into the genomic epidemiology of malaria....
8.
Vanheer L, Mahamar A, Manko E, Niambele S, Sanogo K, Youssouf A, et al.
Sci Rep
. 2023 Jun;
13(1):9522.
PMID: 37308503
Sequence analysis of Plasmodium falciparum parasites is informative in ensuring sustained success of malaria control programmes. Whole-genome sequencing technologies provide insights into the epidemiology and genome-wide variation of P. falciparum...
9.
Moss S, Manko E, Vasileva H, Teixeira da Silva E, Goncalves A, Osborne A, et al.
Sci Rep
. 2023 Apr;
13(1):6311.
PMID: 37072433
Following integrated malaria control interventions, malaria burden on the Bijagós Archipelago has significantly decreased. Understanding the genomic diversity of circulating Plasmodium falciparum malaria parasites can assist infection control, through identifying...
10.
Ibrahim A, Manko E, Dombrowski J, Campos M, Diez Benavente E, Nolder D, et al.
Lancet Reg Health Am
. 2023 Feb;
18:100420.
PMID: 36844008
Background: Brazil is a unique and understudied setting for malaria, with complex foci of transmission associated with human and environmental conditions. An understanding of the population genomic diversity of parasites...