Elliot L Chaikof
Overview
Explore the profile of Elliot L Chaikof including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
229
Citations
5306
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
DeYong A, Li K, Chaikof E
J Org Chem
. 2025 Jan;
90(3):1327-1332.
PMID: 39809455
A scalable, seven step synthesis is reported for a trifluoromethyl toluene protected sulfonated phenylalanine building block whose utility was demonstrated in the synthesis of four CXCR4-derived sulfonopeptides. When compared to...
2.
Intact quantitation and evaluation of a PEG-glycosulfopeptide as a therapeutic P-selectin antagonist
Park D, Park S, Dai E, Haller C, Wong D, Wever W, et al.
RSC Adv
. 2024 Oct;
14(46):34090-34099.
PMID: 39469021
Peptide-based therapeutics are recognized as potent and selective molecules but are often limited by short circulating half-lives, instability towards enzymatic degradation, and immunogenicity. To address these limitations and improve their...
3.
Dhakal B, Mandhapati A, Park S, Sun L, Chaikof E
J Org Chem
. 2024 Aug;
89(16):11641-11658.
PMID: 39087956
We describe the synthesis of a benzoyl-based C2--sLe-Thr-COOH building block devoid of any aglycone transfer or orthoester-formed byproducts. The absence of byproducts was achieved in the course of both [1...
4.
Dhakal B, Mandhapati A, Eradi P, Park S, Fibben K, Li K, et al.
J Am Chem Soc
. 2024 Jun;
146(25):17414-17427.
PMID: 38865166
The high affinity interaction between P-selectin glycoprotein ligand-1 (PSGL-1) and P-selectin is mediated by a multimotif glycosulfopeptide (GSP) recognition domain consisting of clustered tyrosine sulfates and a Core 2 -glycan...
5.
Pandey S, Gao X, Krasnow N, McElroy A, Tao Y, Duby J, et al.
Nat Biomed Eng
. 2024 Jun;
9(1):22-39.
PMID: 38858586
Methods for the targeted integration of genes in mammalian genomes suffer from low programmability, low efficiencies or low specificities. Here we show that phage-assisted continuous evolution enhances prime-editing-assisted site-specific integrase...
6.
Eweje F, Walsh M, Ahmad K, Ibrahim V, Alrefai A, Chen J, et al.
Biomaterials
. 2024 Jan;
305:122464.
PMID: 38181574
To realize the full potential of emerging nucleic acid therapies, there is a need for effective delivery agents to transport cargo to cells of interest. Protein materials exhibit several unique...
7.
Goth C, Mehta A, McQuillan A, Baker K, Hanes M, Park S, et al.
Cell Chem Biol
. 2023 Jul;
30(8):893-905.e7.
PMID: 37463583
Protein glycosylation influences cellular recognition and regulates protein interactions, but how glycosylation functions alongside other common posttranslational modifications (PTMs), like tyrosine sulfation (sTyr), is unclear. We produced a library of...
8.
Kudelka M, Gu W, Matsumoto Y, Ju T, Barnes Ii R, Kardish R, et al.
Glycobiology
. 2023 May;
33(7):567-578.
PMID: 37216646
There is an urgent need to develop new tumor biomarkers for early cancer detection, but the variability of tumor-derived antigens has been a limitation. Here we demonstrate a novel anti-Tn...
9.
Singhal D, Borner K, Chaikof E, Detmar M, Hollmen M, Iliff J, et al.
Front Physiol
. 2023 Feb;
14:1099403.
PMID: 36814475
Enhancing our understanding of lymphatic anatomy from the microscopic to the anatomical scale is essential to discern how the structure and function of the lymphatic system interacts with different tissues...
10.
Ham H, Xu Y, Haller C, Dai E, Stancanelli E, Liu J, et al.
J Med Chem
. 2023 Jan;
66(3):2194-2203.
PMID: 36706244
Heparanase, an endo-β-d-glucuronidase produced by a variety of cells and tissues, cleaves the glycosidic linkage between glucuronic acid (GlcA) and a 3-O- or 6-O-sulfated glucosamine, typified by the disaccharide -[GlcA-GlcNS3S6S]-,...