Elke Bogaert
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Explore the profile of Elke Bogaert including associated specialties, affiliations and a list of published articles.
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27
Citations
1673
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Recent Articles
11.
Versluys L, Ervilha Pereira P, Schuermans N, De Paepe B, De Bleecker J, Bogaert E, et al.
Front Neurosci
. 2022 Feb;
16:815765.
PMID: 35185458
TAR DNA-binding protein 43, mostly referred to as TDP-43 (encoded by the gene) is strongly linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). From the...
12.
Steyaert J, Scheveneels W, Vanneste J, Van Damme P, Robberecht W, Callaerts P, et al.
Hum Mol Genet
. 2018 Nov;
27(23):4103-4116.
PMID: 30379317
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases characterized by the progressive loss of specific groups of neurons. Due to clinical, genetic and pathological overlap, both diseases...
13.
Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield T, Steyaert J, et al.
Cell Rep
. 2018 Jul;
24(3):529-537.e4.
PMID: 30021151
RNA-binding protein aggregation is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To gain better insight into the molecular interactions underlying...
14.
Swinnen B, Bento-Abreu A, Gendron T, Boeynaems S, Bogaert E, Nuyts R, et al.
Acta Neuropathol
. 2018 Jan;
135(3):427-443.
PMID: 29302778
The exact mechanism underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with the GGGGCC repeat expansion in C9orf72 is still unclear. Two gain-of-function mechanisms are possible: repeat RNA...
15.
Boeynaems S, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, et al.
Mol Cell
. 2017 Mar;
65(6):1044-1055.e5.
PMID: 28306503
Liquid-liquid phase separation (LLPS) of RNA-binding proteins plays an important role in the formation of multiple membrane-less organelles involved in RNA metabolism, including stress granules. Defects in stress granule homeostasis...
16.
Boeynaems S, Bogaert E, Van Damme P, Van Den Bosch L
Acta Neuropathol
. 2016 Jun;
132(2):159-173.
PMID: 27271576
Neurodegenerative diseases are characterized by the presence of protein inclusions with a different protein content depending on the type of disease. Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD)...
17.
Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, Jovicic A, et al.
Sci Rep
. 2016 Feb;
6:20877.
PMID: 26869068
Hexanucleotide repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) (c9ALS/FTD). Unconventional translation of these repeats produces dipeptide repeat proteins (DPRs)...
18.
Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada S, et al.
Nat Neurosci
. 2015 Aug;
18(9):1226-9.
PMID: 26308983
C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced by unconventional translation of the C9orf72 repeat expansions cause...
19.
Staats K, Bogaert E, Hersmus N, Jaspers T, Luyten T, Bultynck G, et al.
Biochem Biophys Res Commun
. 2012 Nov;
429(3-4):210-3.
PMID: 23131553
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease causing progressive paralysis of the patient followed by death on average 3-5 years after diagnosis. Disease pathology is multi-factorial including the...
20.
dYdewalle C, Bogaert E, Van Den Bosch L
Traffic
. 2012 Mar;
13(6):771-9.
PMID: 22372633
Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are...