Elizabeth A Makynen
Overview
Explore the profile of Elizabeth A Makynen including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
530
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Recent Articles
1.
Schroeder A, Ankley G, Habib T, Garcia-Reyero N, Escalon B, Jensen K, et al.
Gen Comp Endocrinol
. 2017 Jul;
252:79-87.
PMID: 28736226
Cytochrome P450 aromatase catalyzes conversion of C19 androgens to C18 estrogens and is critical for normal reproduction in female vertebrates. Fadrozole is a model aromatase inhibitor that has been shown...
2.
Milsk R, Cavallin J, Durhan E, Jensen K, Kahl M, Makynen E, et al.
Aquat Toxicol
. 2016 Oct;
180:164-172.
PMID: 27716581
The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal (HPG) axis of fathead minnows (Pimephales promelas) treated with the model androgen receptor (AR) antagonist flutamide. Reproductively-mature...
3.
Villeneuve D, Jensen K, Cavallin J, Durhan E, Garcia-Reyero N, Kahl M, et al.
Environ Toxicol Chem
. 2016 Jun;
36(1):231-242.
PMID: 27312088
Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system. The present study examined the effects of TCC...
4.
Cavallin J, Durhan E, Evans N, Jensen K, Kahl M, Kolpin D, et al.
Environ Toxicol Chem
. 2014 May;
33(8):1849-57.
PMID: 24831736
Animal waste from livestock farming operations can contain varying levels of natural and synthetic androgens and/or estrogens, which can contaminate surrounding waterways. In the present study, surface stream water was...
5.
Kahl M, Villeneuve D, Stevens K, Schroeder A, Makynen E, LaLone C, et al.
Environ Toxicol Chem
. 2014 Mar;
33(7):1584-95.
PMID: 24668901
Assessment of potential risks of complex contaminant mixtures in the environment requires integrated chemical and biological approaches. In support of the US Great Lakes Restoration Initiative, the US Environmental Protection...
6.
LaLone C, Villeneuve D, Cavallin J, Kahl M, Durhan E, Makynen E, et al.
Environ Toxicol Chem
. 2013 Jul;
32(11):2528-41.
PMID: 23881739
Spironolactone is a pharmaceutical that in humans is used to treat conditions like hirsutism, various dermatologic afflictions, and female-pattern hair loss through antagonism of the androgen receptor. Although not routinely...
7.
Bencic D, Villeneuve D, Biales A, Blake L, Durhan E, Jensen K, et al.
Environ Toxicol Chem
. 2013 Apr;
32(8):1828-34.
PMID: 23625624
Gamma-aminobutyric acid (GABA) and GABA receptors play an important role in neuroendocrine regulation in fish. Disruption of the GABAergic system by environmental contaminants could interfere with normal regulation of the...
8.
Villeneuve D, Breen M, Bencic D, Cavallin J, Jensen K, Makynen E, et al.
Toxicol Sci
. 2013 Mar;
133(2):225-33.
PMID: 23492810
Adaptive or compensatory responses to chemical exposure can significantly influence in vivo concentration-duration-response relationships. This study provided data to support development of a computational dynamic model of the hypothalamic-pituitary-gonadal axis...
9.
Skolness S, Blanksma C, Cavallin J, Churchill J, Durhan E, Jensen K, et al.
Toxicol Sci
. 2013 Jan;
132(2):284-97.
PMID: 23339182
Conazoles are designed to inhibit cytochrome P450 (CYP) 14α-demethylase, an enzyme key to fungal cell wall formation. In vertebrates, conazoles may inhibit other CYPs, potentially disrupting processes like sex steroid...
10.
Skolness S, Durhan E, Jensen K, Kahl M, Makynen E, Villeneuve D, et al.
Environ Toxicol Chem
. 2012 Aug;
31(11):2615-24.
PMID: 22911976
Fibrates are a class of pharmaceuticals that indirectly modulate cholesterol biosynthesis through effects on peroxisome proliferator-activated receptors. Gemfibrozil is a fibrate that has been detected in wastewater treatment plant influents,...