Elisabeth R M Tillier
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Explore the profile of Elisabeth R M Tillier including associated specialties, affiliations and a list of published articles.
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19
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862
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Recent Articles
1.
Kathiriya J, Pathak R, Bezginov A, Xue B, Uversky V, Tillier E, et al.
Data Brief
. 2016 Dec;
10:315-324.
PMID: 28004021
We present data on the evolution of intrinsically disordered regions (IDRs) taking into account the entire human protein kinome. The evolutionary data of the IDRs with respect to the kinase...
2.
Kathiriya J, Pathak R, Bezginov A, Xue B, Uversky V, Tillier E, et al.
Biochim Biophys Acta Proteins Proteom
. 2016 Oct;
1865(1):43-54.
PMID: 27718363
Therapeutic protein kinase inhibitors are designed on the basis of kinase structures. Here, we define intrinsically disordered regions (IDRs) in structurally hybrid kinases. We reveal that 65% of kinases have...
3.
Tome S, Manley K, Simard J, Clark G, Slean M, Swami M, et al.
PLoS Genet
. 2013 Mar;
9(2):e1003280.
PMID: 23468640
Expansions of trinucleotide CAG/CTG repeats in somatic tissues are thought to contribute to ongoing disease progression through an affected individual's life with Huntington's disease or myotonic dystrophy. Broad ranges of...
4.
Bezginov A, Clark G, Charlebois R, Dar V, Tillier E
Mol Biol Evol
. 2012 Sep;
30(2):332-46.
PMID: 22977115
Protein interaction networks play central roles in biological systems, from simple metabolic pathways through complex programs permitting the development of organisms. Multicellularity could only have arisen from a careful orchestration...
5.
Havugimana P, Hart G, Nepusz T, Yang H, Turinsky A, Li Z, et al.
Cell
. 2012 Sep;
150(5):1068-81.
PMID: 22939629
Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an...
6.
Clark G, Dar V, Bezginov A, Yang J, Charlebois R, Tillier E
Methods Mol Biol
. 2011 Aug;
781:237-56.
PMID: 21877284
Bioinformatic methods to predict protein-protein interactions (PPI) via coevolutionary analysis have -positioned themselves to compete alongside established in vitro methods, despite a lack of understanding for the underlying molecular mechanisms...
7.
Wang L, Mavisakalyan V, Tillier E, Clark G, Savchenko A, Yakunin A, et al.
Microb Biotechnol
. 2011 Jan;
3(6):677-90.
PMID: 21255363
One hundred and seventy-one genes encoding potential esterases from 11 bacterial genomes were cloned and overexpressed in Escherichia coli; 74 of the clones produced soluble proteins. All 74 soluble proteins...
8.
Clark G, Tillier E
Biochem Cell Biol
. 2010 May;
88(2):185-94.
PMID: 20453921
GroEL is a chaperone thought of as essential for bacterial life. However, some species of Mollicutes are missing GroEL. We use phylogenetic analysis to show that the presence of GroEL...
9.
Xu Y, Tillier E
Proteins
. 2009 Sep;
78(3):548-58.
PMID: 19768681
Correlated mutation analysis (CMA) is an effective approach for predicting functional and structural residue interactions from multiple sequence alignments (MSAs) of proteins. As nearby residues may also play a role...
10.
Tillier E, Charlebois R
Genome Res
. 2009 Aug;
19(10):1861-71.
PMID: 19696150
Coevolution maintains interactions between phenotypic traits through the process of reciprocal natural selection. Detecting molecular coevolution can expose functional interactions between molecules in the cell, generating insights into biological processes,...