Elisa Espinet
Overview
Explore the profile of Elisa Espinet including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1791
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Recent Articles
1.
Marker T, Steimbach R, Perez-Borrajero C, Luzarowski M, Hartmann E, Schleich S, et al.
Nat Chem
. 2025 Feb;
PMID: 39979415
Proton pump inhibitors have become top-selling drugs worldwide. Serendipitously discovered as prodrugs that are activated by protonation in acidic environments, proton pump inhibitors inhibit stomach acid secretion by covalently modifying...
2.
Klein L, Tu M, Krebs N, Urbach L, Grimm D, Latif M, et al.
Nat Commun
. 2025 Jan;
16(1):335.
PMID: 39762215
Pancreatic ductal adenocarcinoma (PDAC) displays a high degree of spatial subtype heterogeneity and co-existence, linked to a diverse microenvironment and worse clinical outcome. However, the underlying mechanisms remain unclear. Here,...
3.
4.
Lopez-Gil J, Garcia-Silva S, Ruiz-Canas L, Navarro D, Palencia-Campos A, Giraldez-Trujillo A, et al.
Gut
. 2024 May;
73(9):1489-1508.
PMID: 38754953
Objective: Pancreatic ductal adenocarcinoma (PDAC) has limited therapeutic options, particularly with immune checkpoint inhibitors. Highly chemoresistant 'stem-like' cells, known as cancer stem cells (CSCs), are implicated in PDAC aggressiveness. Thus,...
5.
Lara O, Janssen P, Mambretti M, De Pauw L, Ates G, Mackens L, et al.
Brain Behav Immun
. 2024 Mar;
118:275-286.
PMID: 38447884
xCT (Slc7a11), the specific subunit of the cystine/glutamate antiporter system x, is present in the brain and on immune cells, where it is known to modulate behavior and inflammatory responses....
6.
Alborzinia H, Chen Z, Yildiz U, Porto Freitas F, Vogel F, Varga J, et al.
EMBO Mol Med
. 2023 Jul;
15(8):e18014.
PMID: 37435859
Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities that could be harnessed for therapeutic benefit. Using CRISPR-activation screens in...
7.
Penuelas-Haro I, Espinet E
EMBO J
. 2023 Jun;
42(14):e114282.
PMID: 37312634
How pancreatic cancer cells acquire tumor initiating capacities remains poorly understood. A recent study by Yamazaki et al (2023) uncovers a crucial, targetable role of tyrosine kinase-like orphan receptor (ROR1)...
8.
Saini M, Schmidleitner L, Moreno H, Donato E, Falcone M, Bartsch J, et al.
Cell Rep
. 2023 May;
42(6):112533.
PMID: 37257449
The acquisition of mesenchymal traits is considered a hallmark of breast cancer progression. However, the functional relevance of epithelial-to-mesenchymal transition (EMT) remains controversial and context dependent. Here, we isolate epithelial...
9.
Wiedmann L, De Angelis Rigotti F, Vaquero-Siguero N, Donato E, Espinet E, Moll I, et al.
Nat Commun
. 2023 Apr;
14(1):2353.
PMID: 37095087
Pancreatic ductal adenocarcinoma (PDAC) frequently metastasizes into the peritoneum, which contributes to poor prognosis. Metastatic spreading is promoted by cancer cell plasticity, yet its regulation by the microenvironment is incompletely...
10.
Pohl S, Llamazares Prada M, Espinet E, Jurkowska R
Methods Mol Biol
. 2022 Dec;
2584:371-387.
PMID: 36495461
Single-cell and single-nucleus RNA sequencing have revolutionized biomedical research, allowing analysis of complex tissues, identification of novel cell types, and mapping of development as well as disease states. Successful application...