Elia Aguado-Fraile
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Explore the profile of Elia Aguado-Fraile including associated specialties, affiliations and a list of published articles.
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14
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600
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Recent Articles
1.
Gounder M, Johnson M, Heist R, Shapiro G, Postel-Vinay S, Wilson F, et al.
Nat Commun
. 2025 Jan;
16(1):423.
PMID: 39762248
Homozygous MTAP deletion occurs in ~15% of cancers, making them vulnerable to decreases in the concentration of S-adenosylmethionine (SAM). AG-270/S095033 is an oral, potent, reversible inhibitor of methionine adenosyltransferase 2 ...
2.
Xu H, George E, Gallo D, Medvedev S, Wang X, Kryczka R, et al.
Res Sq
. 2024 Feb;
PMID: 38410486
Ovarian cancers (OVCAs) and endometrial cancers (EMCAs) with amplification are often resistant to standard of care treatment and represent an unmet clinical need. Previously, synthetic-lethal screening identified loss of the...
3.
Zhu A, Macarulla T, Javle M, Kelley R, Lubner S, Adeva J, et al.
JAMA Oncol
. 2021 Sep;
7(11):1669-1677.
PMID: 34554208
Importance: Isocitrate dehydrogenase 1 (IDH1) variations occur in up to approximately 20% of patients with intrahepatic cholangiocarcinoma. In the ClarIDHy trial, progression-free survival as determined by central review was significantly...
4.
Aguado-Fraile E, Tassinari A, Ishii Y, Sigel C, Lowery M, Goyal L, et al.
Future Oncol
. 2021 Mar;
17(16):2057-2074.
PMID: 33709779
mutations occur in approximately 13% of intrahepatic cholangiocarcinomas (IHCCs). The oral, targeted, mutant IDH1 (mIDH1) inhibitor ivosidenib (AG-120) suppresses production of the oncometabolite D-2-hydroxyglutarate, promoting disease stabilization and improved progression-free...
5.
Kalev P, Hyer M, Gross S, Konteatis Z, Chen C, Fletcher M, et al.
Cancer Cell
. 2021 Jan;
39(2):209-224.e11.
PMID: 33450196
The methylthioadenosine phosphorylase (MTAP) gene is located adjacent to the cyclin-dependent kinase inhibitor 2A (CDKN2A) tumor-suppressor gene and is co-deleted with CDKN2A in approximately 15% of all cancers. This co-deletion...
6.
Lowery M, Burris 3rd H, Janku F, Shroff R, Cleary J, Azad N, et al.
Lancet Gastroenterol Hepatol
. 2019 Jul;
4(9):711-720.
PMID: 31300360
Background: Isocitrate dehydrogenase-1 (IDH1) is mutated in up to 25% of cholangiocarcinomas, especially intrahepatic cholangiocarcinoma. Ivosidenib is an oral, targeted inhibitor of mutant IDH1 (mIDH1) approved in the USA for...
7.
Serebrennikova O, Paraskevopoulou M, Aguado-Fraile E, Taraslia V, Ren W, Thapa G, et al.
Proc Natl Acad Sci U S A
. 2019 Jun;
116(28):14039-14048.
PMID: 31239343
Most normal and tumor cells are protected from tumor necrosis factor α (TNFα)-induced apoptosis. Here, we identify the MAP3 kinase tumor progression locus-2 (TPL2) as a player contributing to the...
8.
Conde E, Gimenez-Moyano S, Martin-Gomez L, Rodriguez M, Ramos M, Aguado-Fraile E, et al.
Sci Rep
. 2017 Jan;
7:41099.
PMID: 28106131
Ischemia/reperfusion (I/R) leads to Acute Kidney Injury. HIF-1α is a key factor during organ response to I/R. We previously demonstrated that HIF-1α is induced during renal reperfusion, after ischemia. Here...
9.
A Pilot Study Identifying a Set of microRNAs As Precise Diagnostic Biomarkers of Acute Kidney Injury
Aguado-Fraile E, Ramos E, Conde E, Rodriguez M, Martin-Gomez L, Lietor A, et al.
PLoS One
. 2015 Jun;
10(6):e0127175.
PMID: 26079930
In the last decade, Acute Kidney Injury (AKI) diagnosis and therapy have not notably improved probably due to delay in the diagnosis, among other issues. Precocity and accuracy should be...
10.
Aguado-Fraile E, Ramos E, Conde E, Rodriguez M, Liano F, Garcia-Bermejo M
Nefrologia
. 2013 Oct;
33(6):826-34.
PMID: 24158125
microRNAs are small, endogenous RNA molecules which are critical for a new step in the regulation of the gene expression. They have become the most critical biological mediators characterized in...