Eleni Jaecklein
Overview
Explore the profile of Eleni Jaecklein including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
9
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0
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Recent Articles
1.
Simwela N, Jaecklein E, Sassetti C, Russell D
Elife
. 2025 Mar;
13.
PMID: 40080408
() infection of macrophages reprograms cellular metabolism to promote lipid retention. While it is clearly known that intracellular utilize host-derived lipids to maintain infection, the role of macrophage lipid processing...
2.
Jaecklein E, Papavinasasundaram K, Ostroff G, Sassetti C, Soto E
Microbiol Spectr
. 2025 Feb;
13(3):e0274424.
PMID: 39912634
Importance: Tuberculosis (TB) causes an estimated 10.8 million cases each year and remains one of the leading causes of infectious death. Effective treatment is complicated due to the lengthy drug...
3.
Luna M, Oluoch P, Miao J, Culviner P, Papavinasasundaram K, Jaecklein E, et al.
mBio
. 2025 Jan;
16(3):e0376224.
PMID: 39873486
Importance: (Mtb) is responsible for more deaths worldwide than any other single infectious agent. Understanding how this pathogen adapts to the varied environmental pressures imposed by host immunity and antibiotics...
4.
Simwela N, Johnston L, Bitar P, Jaecklein E, Altier C, Sassetti C, et al.
Nat Commun
. 2024 Oct;
15(1):9322.
PMID: 39472457
The eukaryotic Glucose Induced Degradation/C-Terminal to LisH (GID/CTLH) complex is a highly conserved E3 ubiquitin ligase involved in a broad range of biological processes. However, a role of this complex...
5.
Simwela N, Jaecklein E, Sassetti C, Russell D
bioRxiv
. 2024 Aug;
PMID: 39091727
infection of macrophages reprograms cellular metabolism to promote lipid retention. While it is clearly known that intracellular utilize host derived lipids to maintain infection, the role of macrophage lipid processing...
6.
Simwela N, Johnston L, Bitar P, Jaecklein E, Altier C, Sassetti C, et al.
bioRxiv
. 2024 May;
PMID: 38766174
Graphical Abstract:
7.
Cai Y, Jaecklein E, Mackenzie J, Papavinasasundaram K, Olive A, Chen X, et al.
PLoS Pathog
. 2021 Jul;
17(7):e1008911.
PMID: 34320028
In order to sustain a persistent infection, Mycobacterium tuberculosis (Mtb) must adapt to a changing environment that is shaped by the developing immune response. This necessity to adapt is evident...