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Elaine Langenfeld

Explore the profile of Elaine Langenfeld including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 105
Followers 0
Related Specialties
Oncology
Molecular Biology
Biochemistry
Top 10 Co-Authors
John Langenfeld
Salma K Jabbour
Rachel NeMoyer
Arindam Mondal
Mehul Vora
David J Augeri
Youyi Peng
Christopher Rongo
Dongxuan Jia
Monica Castle
Published In
Cell Commun Signal
Mol Cancer
PLoS One
Oncogene
Affiliations
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Recent Articles
1.
Bone morphogenetic protein receptor 2 inhibition destabilizes microtubules promoting the activation of lysosomes and cell death of lung cancer cells
Mondal A, NeMoyer R, Vora M, Napoli L, Syed Z, Langenfeld E, et al.
Cell Commun Signal . 2021 Sep; 19(1):97. PMID: 34563224
Background: Recent studies have shown that bone morphogenetic protein receptor 2 (BMPR2) regulates cell survival signaling events in cancer cells independent of the BMP type 1 receptor (BMPR1) or the...
2.
Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein
NeMoyer R, Mondal A, Vora M, Langenfeld E, Glover D, Scott M, et al.
Cell Commun Signal . 2019 Nov; 17(1):150. PMID: 31744505
No abstract available.
3.
Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer
Newman J, Augeri D, NeMoyer R, Malhotra J, Langenfeld E, Chesson C, et al.
Oncogene . 2018 Apr; 37(27):3672-3685. PMID: 29622797
BMP receptor inhibitors induce death of cancer cells through the downregulation of antiapoptotic proteins XIAP, pTAK1, and Id1-Id3. However, the current most potent BMP receptor inhibitor, DMH2, does not downregulate...
4.
Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death
Augeri D, Langenfeld E, Castle M, Gilleran J, Langenfeld J
Mol Cancer . 2016 Apr; 15:27. PMID: 27048361
Background: Bone morphogenetic proteins (BMP) are embryonic proteins that are part of the transforming growth factor (TGFβ) superfamily, which are aberrantly expressed in many carcinomas. Inhibition of BMP receptors with...
5.
Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct4 or nestin
Langenfeld E, Deen M, Zachariah E, Langenfeld J
Mol Cancer . 2013 Oct; 12(1):129. PMID: 24160469
Background: Bone morphogenetic proteins (BMP) are embryonic morphogens that are aberrantly expressed in lung cancer. BMPs mediate cell fate decisions and self-renewal of stem cells, through transcription regulation of inhibitor...
6.
Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines
Langenfeld E, Hong C, Lanke G, Langenfeld J
PLoS One . 2013 Apr; 8(4):e61256. PMID: 23593444
Bone morphogenetic proteins (BMPs) are highly conserved morphogens that are essential for normal development. BMP-2 is highly expressed in the majority of non-small cell lung carcinomas (NSCLC) but not in...