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Eiichi Kodama

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Recent Articles
11.
Siarot L, Chutiwitoonchai N, Sato H, Chang H, Sato H, Fujino M, et al.
Biochem Biophys Res Commun . 2018 Aug; 503(4):2970-2976. PMID: 30126636
The interaction between viral protein Gag and cellular protein tumor susceptibility gene 101 (TSG101) is a crucial step in the HIV-1 replication cycle. This interaction initiates the viral assembly/budding via...
12.
Fujiwara S, Kimura H, Imadome K, Arai A, Kodama E, Morio T, et al.
Pediatr Int . 2014 Feb; 56(2):159-66. PMID: 24528553
Epstein-Barr virus (EBV) infection is usually asymptomatic and persists lifelong. Although EBV-infected B cells have the potential for unlimited proliferation, they are effectively removed by the virus-specific cytotoxic T cells,...
13.
Masuda R, Oishi S, Tanahara N, Ohno H, Hirasawa A, Tsujimoto G, et al.
Future Med Chem . 2012 May; 4(7):837-44. PMID: 22571609
Background: SDF-1/CXCR4 signaling plays key roles in directed cell migration under physiological and pathological conditions. To develop agonist-based CXCR4 probes for detection of CXCR4 expression on cell lines and metastatic...
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Narumi T, Hayashi R, Tomita K, Kobayashi K, Tanahara N, Ohno H, et al.
Org Biomol Chem . 2010 Jan; 8(3):616-21. PMID: 20090978
A set of cyclic peptide analogues of a selective CXCR4 antagonist FC131 [cyclo(-d-Tyr-Arg-Arg-Nal-Gly-)] were synthesized and bioevaluated. Using (E)-alkene and (Z)-fluoroalkene dipeptide isosteres for Arg-Arg and Arg-Nal substructures, indispensable or...
16.
Kajiwara K, Watanabe K, Tokiwa R, Kurose T, Ohno H, Tsutsumi H, et al.
Bioorg Med Chem . 2009 Oct; 17(23):7964-70. PMID: 19864148
The bioorganic synthesis of an end-capped anti-HIV peptide from a recombinant protein was investigated. Cyanogen bromide-mediated cleavage of two Met-Gln sites across the target anti-HIV sequence generated an HIV-1 fusion...
17.
Tanaka M, Kajiwara K, Tokiwa R, Watanabe K, Ohno H, Tsutsumi H, et al.
Bioorg Med Chem . 2009 Oct; 17(21):7487-92. PMID: 19811922
Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides.
18.
Watabe T, Terakawa Y, Watanabe K, Ohno H, Nakano H, Nakatsu T, et al.
J Mol Biol . 2009 Jul; 392(3):657-65. PMID: 19616557
The S138A substitution of fusion inhibitory peptides derived from the C-terminal heptad repeat (C-HR) of the human immunodeficiency virus type 1 (HIV-1) gp41 leads to enhanced binding affinity to the...
19.
Oishi S, Kamitani H, Kodera Y, Watanabe K, Kobayashi K, Narumi T, et al.
Org Biomol Chem . 2009 Jul; 7(14):2872-7. PMID: 19582296
The alpha-helix structures of the anti-HIV fusion inhibitory peptides are stabilized by the amino acid sequence and by intrachain hydrogen bonds. The study of peptide analogues using (E)-alkene and (Z)-fluoroalkene...
20.
Oishi S, Kodera Y, Nishikawa H, Kamitani H, Watabe T, Ohno H, et al.
Bioorg Med Chem . 2009 Jun; 17(14):4916-20. PMID: 19541488
Feline immunodeficiency virus (FIV) is a pathogenic virus that causes an AIDS-like syndrome in the domestic cats. For viral entry and infection, fusion between the virus and the cell membrane...