Ehud Y Isacoff
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Explore the profile of Ehud Y Isacoff including associated specialties, affiliations and a list of published articles.
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149
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Recent Articles
11.
Casiraghi M, Wang H, Brennan P, Habrian C, Hubner H, Schmidt M, et al.
bioRxiv
. 2024 Apr;
PMID: 38586060
G protein coupled receptors (GPCRs) exhibit varying degrees of selectivity for different G protein isoforms. Despite the abundant structures of GPCR-G protein complexes, little is known about the mechanism of...
12.
Latorraca N, Sabaat S, Habrian C, Bleier J, Stanley C, Marqusee S, et al.
bioRxiv
. 2024 Mar;
PMID: 38464305
The G protein-coupled metabotropic glutamate receptors form homodimers and heterodimers with highly diverse responses to glutamate and varying physiological function. The molecular basis for this diversity remains poorly delineated. We...
13.
Bleier J, Furtado de Mendonca P, Habrian C, Stanley C, Vyklicky V, Isacoff E
bioRxiv
. 2024 Feb;
PMID: 38370786
N-methyl-D-aspartate receptors are ionotropic glutamate receptors that are integral to synaptic transmission and plasticity. Variable GluN2 subunits in diheterotetrameric receptors with identical GluN1 subunits set very different functional properties, which...
14.
Habrian C, Latorraca N, Fu Z, Isacoff E
Nat Commun
. 2023 Dec;
14(1):8288.
PMID: 38092773
Metabotropic glutamate receptors (mGluRs) are dimeric class C G-protein-coupled receptors that operate in glia and neurons. Glutamate affinity and efficacy vary greatly between the eight mGluRs. The molecular basis of...
15.
Deal P, Lee H, Mondal A, Lolicato M, Furtado de Mendonca P, Black H, et al.
bioRxiv
. 2023 Oct;
PMID: 37905049
K potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune cells, and sensory organs. Despite their important roles in anesthesia, arrhythmia, pain, hypertension,...
16.
Winans A, Friedmann D, Stanley C, Xiao T, Liu T, Chang C, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(43):e2311131120.
PMID: 37844228
Many neurons in the central nervous system produce a single primary cilium that serves as a specialized signaling organelle. Several neuromodulatory G-protein-coupled receptors (GPCRs) localize to primary cilia in neurons,...
17.
Kumar K, Wang H, Habrian C, Latorraca N, Xu J, OBrien E, et al.
bioRxiv
. 2023 Sep;
PMID: 37693614
Metabotropic glutamate receptors belong to a family of G protein-coupled receptors that are obligate dimers and possess a large extracellular ligand-binding domain (ECD) that is linked via a cysteine-rich domain...
18.
Hetzler B, Donthamsetti P, Peitsinis Z, Stanley C, Trauner D, Isacoff E
J Am Chem Soc
. 2023 Aug;
145(34):18778-18788.
PMID: 37586061
Dopamine D2-like receptors (D2R, D3R, and D4R) control diverse physiological and behavioral functions and are important targets for the treatment of a variety of neuropsychiatric disorders. Their complex distribution and...
19.
Kumar K, OBrien E, Habrian C, Latorraca N, Wang H, Tuneew I, et al.
Cell
. 2023 Mar;
186(7):1465-1477.e18.
PMID: 37001505
Receptor activity-modifying proteins (RAMPs) modulate the activity of many Family B GPCRs. We show that RAMP2 directly interacts with the glucagon receptor (GCGR), a Family B GPCR responsible for blood...
20.
Kern D, Bleier J, Mukherjee S, Hill J, Kossiakoff A, Isacoff E, et al.
Nat Struct Mol Biol
. 2023 Mar;
30(6):841-852.
PMID: 36928458
Leucine-rich repeat-containing protein 8 (LRRC8) family members form volume-regulated anion channels activated by hypoosmotic cell swelling. LRRC8 channels are ubiquitously expressed in vertebrate cells as heteromeric assemblies of LRRC8A (SWELL1)...