Eeson Rajendra
Overview
Explore the profile of Eeson Rajendra including associated specialties, affiliations and a list of published articles.
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25
Citations
1254
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0
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Recent Articles
1.
Grande D, Rajendra E, Mason B, Galbiati A, Boulton S, Smith G, et al.
J Vis Exp
. 2024 Jul;
(208).
PMID: 38949387
The repair of DNA double strand breaks (DSBs) is crucial for the maintenance of genome stability and cell viability. DSB repair (DSBR) in cells is mediated through several mechanisms: homologous...
2.
Pilie P, Giuliani V, Wang W, McGrail D, Bristow C, Ngoi N, et al.
Clin Cancer Res
. 2024 Feb;
30(10):2121-2139.
PMID: 38416404
Purpose: Mutations in the ATM gene are common in multiple cancers, but clinical studies of therapies targeting ATM-aberrant cancers have yielded mixed results. Refinement of ATM loss of function (LOF)...
3.
Rajendra E, Grande D, Mason B, Di Marcantonio D, Armstrong L, Hewitt G, et al.
Nucleic Acids Res
. 2023 Dec;
52(4):1736-1752.
PMID: 38109306
Repair of DNA damage is essential for the maintenance of genome stability and cell viability. DNA double strand breaks (DSBs) constitute a toxic class of DNA lesion and multiple cellular...
4.
Stockley M, Benedetti G, Blencowe P, Boulton S, Boyd S, Calder M, et al.
J Med Chem
. 2023 Feb;
PMID: 36815444
No abstract available.
5.
Rodriguez-Berriguete G, Ranzani M, Prevo R, Puliyadi R, Machado N, Bolland H, et al.
Clin Cancer Res
. 2023 Jan;
29(8):1631-1642.
PMID: 36689546
Purpose: DNA polymerase theta (Polθ, encoded by the POLQ gene) is a DNA repair enzyme critical for microhomology mediated end joining (MMEJ). Polθ has limited expression in normal tissues but...
6.
Stockley M, Ferdinand A, Benedetti G, Blencowe P, Boyd S, Calder M, et al.
J Med Chem
. 2022 Oct;
65(20):13879-13891.
PMID: 36200480
Human DNA polymerase theta (Polθ), which is essential for microhomology-mediated DNA double strand break repair, has been proposed as an attractive target for the treatment of BRCA deficient and other...
7.
Zatreanu D, Robinson H, Alkhatib O, Boursier M, Finch H, Geo L, et al.
Nat Commun
. 2021 Jun;
12(1):3636.
PMID: 34140467
To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric inhibitors of the polymerase function of DNA polymerase Polθ, including...
8.
Shakeel S, Rajendra E, Alcon P, OReilly F, Chorev D, Maslen S, et al.
Nature
. 2019 Nov;
575(7781):234-237.
PMID: 31666700
The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress. Genetic inactivation of this pathway by mutation of genes encoding...
9.
Petela N, Gligoris T, Metson J, Lee B, Voulgaris M, Hu B, et al.
Mol Cell
. 2018 Jun;
70(6):1134-1148.e7.
PMID: 29932904
Cohesin organizes DNA into chromatids, regulates enhancer-promoter interactions, and confers sister chromatid cohesion. Its association with chromosomes is regulated by hook-shaped HEAT repeat proteins that bind Scc1, namely Scc3, Pds5,...
10.
Bai X, Rajendra E, Yang G, Shi Y, Scheres S
Elife
. 2015 Dec;
4.
PMID: 26623517
Human γ-secretase is an intra-membrane protease that cleaves many different substrates. Aberrant cleavage of Notch is implicated in cancer, while abnormalities in cutting amyloid precursor protein lead to Alzheimer's disease....