Eek Joong Park
Overview
Explore the profile of Eek Joong Park including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
13
Citations
1771
Followers
0
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Recent Articles
1.
Inokuchi-Shimizu S, Park E, Roh Y, Yang L, Zhang B, Song J, et al.
J Clin Invest
. 2014 Jul;
124(8):3566-78.
PMID: 24983318
The MAP kinase kinase kinase TGFβ-activated kinase 1 (TAK1) is activated by TLRs, IL-1, TNF, and TGFβ and in turn activates IKK-NF-κB and JNK, which regulate cell survival, growth, tumorigenesis,...
2.
Umemura A, Park E, Taniguchi K, Lee J, Shalapour S, Valasek M, et al.
Cell Metab
. 2014 Jun;
20(1):133-44.
PMID: 24910242
Obesity can result in insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH) and increases liver cancer risk. Obesity-induced insulin resistance depends, in part, on chronic activation of mammalian target of rapamycin...
3.
Moles A, Murphy L, Wilson C, Bagchi Chakraborty J, Fox C, Park E, et al.
J Hepatol
. 2013 Dec;
60(4):782-91.
PMID: 24333183
Background & Aims: Neutrophils are important immune effectors required for sterile and non-sterile inflammatory responses. However, neutrophils are associated with pathology in drug-induced liver injury, acute alcoholic liver disease, and...
4.
Yang L, Inokuchi S, Roh Y, Song J, Loomba R, Park E, et al.
Gastroenterology
. 2013 Feb;
144(5):1042-1054.e4.
PMID: 23391818
Background & Aims: Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is activated in different cytokine signaling pathways. Deletion of Tak1 from hepatocytes results in spontaneous development of hepatocellular carcinoma (HCC),...
5.
Lee J, Budanov A, Talukdar S, Park E, Park H, Park H, et al.
Cell Metab
. 2012 Sep;
16(3):311-21.
PMID: 22958918
Chronic activation of mammalian target of rapamycin complex 1 (mTORC1) and p70 S6 kinase (S6K) in response to hypernutrition contributes to obesity-associated metabolic pathologies, including hepatosteatosis and insulin resistance. Sestrins...
6.
Ali S, Timmer A, Bilgrami S, Park E, Eckmann L, Nizet V, et al.
Immunity
. 2011 Jun;
35(1):34-44.
PMID: 21683629
Detection of microbial constituents by membrane associated and cytoplasmic pattern recognition receptors is the essence of innate immunity, leading to activation of protective host responses. However, it is still unclear...
7.
Lee J, Budanov A, Park E, Birse R, Kim T, Perkins G, et al.
Science
. 2010 Mar;
327(5970):1223-8.
PMID: 20203043
Sestrins are conserved proteins that accumulate in cells exposed to stress, potentiate adenosine monophosphate-activated protein kinase (AMPK), and inhibit activation of target of rapamycin (TOR). We show that the abundance...
8.
Park E, Lee J, Yu G, He G, Ali S, Holzer R, et al.
Cell
. 2010 Feb;
140(2):197-208.
PMID: 20141834
Epidemiological studies indicate that overweight and obesity are associated with increased cancer risk. To study how obesity augments cancer risk and development, we focused on hepatocellular carcinoma (HCC), the common...
9.
Park E, Suh M, Thomson B, Ma D, Ramanujam K, Thomson A, et al.
Shock
. 2007 May;
28(1):112-7.
PMID: 17510604
Our previous study demonstrated that feeding ganglioside increased total ganglioside content while decreasing cholesterol and caveolin-1 content in developing rat intestinal lipid microdomains. Cholesterol or caveolin depletion in membranes inhibits...
10.
Birecki C, Drozdowski L, Suh M, Park E, Clandinin M, Thomson A
J Pediatr Gastroenterol Nutr
. 2005 Dec;
42(1):59-65.
PMID: 16385255
Background: The intestine adapts morphologically or functionally in response to environmental stimuli. Dietary lipids modify brush border membrane (BBM) permeability and nutrient transporter activities. Gangliosides (GANG) are glycolipids in human...