Edwin R Speck
Overview
Explore the profile of Edwin R Speck including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
613
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Recent Articles
1.
Kapur R, Aslam R, Speck E, Rebetz J, Semple J
Platelets
. 2019 Jun;
31(3):399-402.
PMID: 31146647
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which autoantibodies and/or autoreactive T cells destroy platelets and megakaryocytes in the spleen and bone marrow, respectively. Thrombopoietin receptor agonists (TPO-RA...
2.
Kapur R, Kim M, Rebetz J, Hallstrom B, Bjorkman J, Takabe-French A, et al.
Blood Adv
. 2018 Jul;
2(13):1651-1663.
PMID: 29991496
Transfusion-related acute lung injury (TRALI) is a syndrome of respiratory distress upon blood transfusion and is the leading cause of transfusion-related fatalities. Whether the gut microbiota plays any role in...
3.
Zufferey A, Speck E, Machlus K, Aslam R, Guo L, McVey M, et al.
Blood Adv
. 2018 Jan;
1(20):1773-1785.
PMID: 29296823
Megakaryocytes (MKs) are bone marrow-derived cells that are primarily responsible for generating platelets for the maintenance of hemostasis. Although MK can variably express major histocompatibility complex (MHC) class I and...
4.
Kapur R, Catalina M, Aslam R, Speck E, Francovitch R, Semple J
Br J Haematol
. 2017 Oct;
183(3):501-503.
PMID: 29048127
No abstract available.
5.
Kapur R, Kim M, Aslam R, McVey M, Tabuchi A, Luo A, et al.
Blood
. 2017 Feb;
129(18):2557-2569.
PMID: 28202460
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis...
6.
Amatullah H, Shan Y, Beauchamp B, Gali P, Gupta S, Maron-Gutierrez T, et al.
Am J Respir Crit Care Med
. 2016 Oct;
195(7):889-905.
PMID: 27735193
Rationale: Effective and rapid bacterial clearance is a fundamental determinant of outcomes in sepsis. DJ-1 is a well-established reactive oxygen species (ROS) scavenger. Objectives: Because cellular ROS status is pivotal...
7.
Guo L, Kapur R, Aslam R, Speck E, Zufferey A, Zhao Y, et al.
Blood
. 2015 Nov;
127(6):735-8.
PMID: 26556550
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with a complex pathogenesis, which includes both antibody- and T-cell-mediated effector mechanisms. Rituximab (an anti-human CD20 monoclonal antibody [mAb]) is one of...
8.
Guo L, Yang L, Speck E, Aslam R, Kim M, McKenzie C, et al.
Blood
. 2013 Nov;
123(3):422-7.
PMID: 24258817
Platelet transfusions are life-saving treatments for many patients with thrombocytopenia; however, their use is generally discouraged in the autoimmune disorder known as immune thrombocytopenia (ITP). We examined whether allogeneic platelet...
9.
Aslam R, Hu Y, Gebremeskel S, Segel G, Speck E, Guo L, et al.
Blood
. 2012 Jul;
120(10):2127-32.
PMID: 22760780
Immune thrombocytopenia (ITP) is a bleeding disorder in which antibodies and/or T cells lead to enhanced peripheral platelet destruction and reduced bone marrow platelet production. Several reports have observed that...
10.
Fung Y, Kim M, Tabuchi A, Aslam R, Speck E, Chow L, et al.
Blood
. 2010 Jul;
116(16):3073-9.
PMID: 20616220
Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion and has been ranked as one of the leading causes of transfusion-related fatalities. Nonetheless, many details of the immunopathogenesis...