Edward W Kraegen
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Explore the profile of Edward W Kraegen including associated specialties, affiliations and a list of published articles.
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53
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Recent Articles
1.
Brandon A, Stuart E, Leslie S, Hoehn K, James D, Kraegen E, et al.
J Endocrinol
. 2015 Dec;
228(3):127-34.
PMID: 26668208
An important regulator of fatty acid oxidation (FAO) is the allosteric inhibition of CPT-1 by malonyl-CoA produced by the enzyme acetyl-CoA carboxylase 2 (ACC2). Initial studies suggested that deletion of...
2.
Coughlan K, Balon T, Valentine R, Petrocelli R, Schultz V, Brandon A, et al.
PLoS One
. 2015 May;
10(5):e0127388.
PMID: 25996822
We have previously shown that incubation for 1h with excess glucose or leucine causes insulin resistance in rat extensor digitorum longus (EDL) muscle by inhibiting AMP-activated protein kinase (AMPK). To...
3.
Brandon A, Tid-Ang J, Wright L, Stuart E, Suryana E, Bentley N, et al.
PLoS One
. 2015 Mar;
10(3):e0121959.
PMID: 25798922
SIRT1 is a NAD+-dependent deacetylase thought to regulate cellular metabolic pathways in response to alterations in nutrient flux. In the current study we investigated whether acute changes in SIRT1 expression...
4.
Turner N, Cooney G, Kraegen E, Bruce C
J Endocrinol
. 2013 Dec;
220(2):T61-79.
PMID: 24323910
Fatty acids (FAs) are essential elements of all cells and have significant roles as energy substrates, components of cellular structure and signalling molecules. The storage of excess energy intake as...
5.
Iseli T, Turner N, Zeng X, Cooney G, Kraegen E, Yao S, et al.
PLoS One
. 2013 May;
8(4):e62309.
PMID: 23638033
We recently showed that bitter melon-derived triterpenoids (BMTs) activate AMPK and increase GLUT4 translocation to the plasma membrane in vitro, and improve glucose disposal in insulin resistant models in vivo....
6.
Zeng X, Wang Y, Cantley J, Iseli T, Molero J, Hegarty B, et al.
PLoS One
. 2012 Aug;
7(7):e42115.
PMID: 22860063
The present study investigated the chronic efficacy of oleanolic acid (OA), a triterpenoid selected from our recent screening, on hyperglycemia in type-2 diabetic mice. C57BL/6J mice were fed a high-fat...
7.
Boden M, Brandon A, Tid-Ang J, Preston E, Wilks D, Stuart E, et al.
Am J Physiol Endocrinol Metab
. 2012 Jul;
303(6):E798-805.
PMID: 22829583
Elevated mitochondrial reactive oxygen species have been suggested to play a causative role in some forms of muscle insulin resistance. However, the extent of their involvement in the development of...
8.
Ren L, Chan S, Zeng X, Laybutt D, Iseli T, Sun R, et al.
PLoS One
. 2012 Feb;
7(2):e30816.
PMID: 22355328
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been implicated in hepatic steatosis and insulin resistance. The present study investigated their roles in the development of hepatic steatosis and insulin...
9.
Saha A, Xu X, Balon T, Brandon A, Kraegen E, Ruderman N
Cell Cycle
. 2011 Nov;
10(20):3447-51.
PMID: 22067655
It has long been known that excesses of glucose and branched chain amino acids, such as leucine, lead to insulin resistance in skeletal muscle. A recent study in incubated rat...
10.
Preston E, Cooney G, Wilks D, Baran K, Zhang L, Kraegen E, et al.
Neuropeptides
. 2011 Aug;
45(6):407-15.
PMID: 21862125
Weight loss inhibits thyrotropic function and reduces metabolic rate, thereby contributing to weight regain. Under negative energy balance there is an increase in the hypothalamic expression of both neuropeptide Y...