Edward S Schelegle
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Explore the profile of Edward S Schelegle including associated specialties, affiliations and a list of published articles.
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66
Citations
981
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Recent Articles
11.
Murphy S, Oslund K, Hyde D, Miller L, Van Winkle L, Schelegle E
Am J Physiol Lung Cell Mol Physiol
. 2014 Jul;
307(6):L471-81.
PMID: 25063800
Children are uniquely susceptible to ozone because airway and lung growth continue for an extensive period after birth. Early-life exposure of the rhesus monkey to repeated ozone cycles results in...
12.
Allen R, Schelegle E, Bennett S
Am J Physiol Heart Circ Physiol
. 2014 May;
307(3):H405-17.
PMID: 24858853
Pulmonary hypertension (PH) is associated with progressive changes in arterial network complexity. An allometric model is derived that integrates diameter branching complexity between pulmonary arterioles of generation n and the...
13.
Mansoor J, Schelegle E, Davis C, Walby W, Zhao W, Aksenov A, et al.
PLoS One
. 2014 Apr;
9(4):e95331.
PMID: 24748102
Background: An important challenge to pulmonary arterial hypertension (PAH) diagnosis and treatment is early detection of occult pulmonary vascular pathology. Symptoms are frequently confused with other disease entities that lead...
14.
Moore B, Hyde D, Miller L, Wong E, Schelegle E
Am J Respir Cell Mol Biol
. 2014 Feb;
51(1):77-85.
PMID: 24484440
The persistence of airway hyperresponsiveness (AHR) and serotonergic enhancement of airway smooth muscle (ASM) contraction induced by ozone (O3) plus allergen has not been evaluated. If this mechanism persists after...
15.
Chun K, Miller L, Schelegle E, Hyde D, Capitanio J
PLoS One
. 2013 Aug;
8(8):e71575.
PMID: 23951195
Behavioral inhibition reflects a disposition to react warily to novel situations, and has been associated with atopic diseases such as asthma. Retrospective work established the relationship between behavioral inhibition in...
16.
Murphy S, Schelegle E, Miller L, Hyde D, Van Winkle L
Toxicol Sci
. 2013 Apr;
134(1):168-79.
PMID: 23570994
Ozone, a pervasive environmental pollutant, adversely affects functional lung growth in children. Animal studies demonstrate that altered lung development is associated with modified signaling within the airway epithelial mesenchymal trophic...
17.
Davis B, Zeki A, Bratt J, Wang L, Filosto S, Walby W, et al.
Eur Respir J
. 2012 Nov;
42(2):350-61.
PMID: 23180589
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death. The statin drugs may have therapeutic potential in respiratory diseases such as COPD, but whether they prevent bronchial...
18.
Murphy S, Schelegle E, Edwards P, Miller L, Hyde D, Van Winkle L
Am J Respir Cell Mol Biol
. 2012 Sep;
47(6):815-23.
PMID: 22962062
Postnatally, the lung continues to grow and differentiate while interacting with the environment. Exposure to ozone (O(3)) and allergens during postnatal lung development alters structural elements of conducting airways, including...
19.
McDonnell W, Stewart P, Smith M, Kim C, Schelegle E
Inhal Toxicol
. 2012 Aug;
24(10):619-33.
PMID: 22906168
Context: A human exposure-response (E-R) model previously demonstrated to accurately predict population mean FEV₁ response to ozone exposure has been proposed as the foundation for future risk assessments for ambient...
20.
Avdalovic M, Tyler N, Putney L, Nishio S, Quesenberry S, Singh P, et al.
Anat Rec (Hoboken)
. 2012 Aug;
295(10):1707-16.
PMID: 22887719
Exposure to oxidant air pollutants in early childhood, with ozone as the key oxidant, has been linked to significant decrements in pulmonary function in young adults and exacerbation of airway...