Edward P Hackett
Overview
Explore the profile of Edward P Hackett including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
89
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hackett E, Chen J, Ingle L, Al Nemri S, Barshikar S, da Cunha Pinho M, et al.
Magn Reson Med
. 2023 Jul;
90(6):2432-2442.
PMID: 37427535
Purpose: [ C]Bicarbonate formation from hyperpolarized [1- C]pyruvate via pyruvate dehydrogenase, a key regulatory enzyme, represents the cerebral oxidation of pyruvate and the integrity of mitochondrial function. The present study...
2.
Chen J, LaGue E, Li J, Yang C, Hackett E, Mendoza M, et al.
Anal Sens
. 2022 Jun;
1(4):196-202.
PMID: 35693130
The interplay between glycolysis and gluconeogenesis is central to carbohydrate metabolism. Here, we describe novel methods to assess carbohydrate metabolism using [C]-probes derived from glycerate, a molecule whose metabolic fate...
3.
Singh J, Suh E, Sharma G, Chen J, Hackett E, Wen X, et al.
Anal Sens
. 2022 Jun;
1(4):156-160.
PMID: 35669533
The TCA cycle is a central metabolic pathway for energy production and biosynthesis. A major control point of metabolic flux through the cycle is the decarboxylation of 2-ketoglutarate by the...
4.
Ma J, Pinho M, Harrison C, Chen J, Sun C, Hackett E, et al.
Magn Reson Med
. 2021 Oct;
87(3):1136-1149.
PMID: 34687086
Purpose: This study is to investigate time-resolved C MR spectroscopy (MRS) as an alternative to imaging for assessing pyruvate metabolism using hyperpolarized (HP) [1- C]pyruvate in the human brain. Methods:...
5.
Hackett E, Shah B, Cheng B, LaGue E, Vemireddy V, Mendoza M, et al.
ACS Chem Neurosci
. 2021 Jul;
12(15):2820-2828.
PMID: 34291630
Transient disruption of the blood-brain barrier (BBB) with focused ultrasound (FUS) is an emerging clinical method to facilitate targeted drug delivery to the brain. The focal noninvasive disruption of the...
6.
Ma J, Chen J, Reed G, Hackett E, Harrison C, Ratnakar J, et al.
Magn Reson Med
. 2021 Apr;
86(3):1494-1504.
PMID: 33821504
Purpose: Noninvasive imaging with hyperpolarized (HP) pyruvate can capture in vivo cardiac metabolism. For proper quantification of the metabolites and optimization of imaging parameters, understanding MR characteristics such as s...
7.
Hackett E, Pinho M, Harrison C, Reed G, Liticker J, Raza J, et al.
iScience
. 2020 Dec;
23(12):101885.
PMID: 33344923
Traumatic brain injury (TBI) involves complex secondary injury processes following the primary injury. The secondary injury is often associated with rapid metabolic shifts and impaired brain function immediately after the...
8.
Chen J, Hackett E, Kovacs Z, Malloy C, Park J
Magn Reson Med
. 2020 Sep;
85(3):1175-1182.
PMID: 32936474
Purpose: To evaluate the utility of hyperpolarized [1- C]-l-lactate to detect hepatic pyruvate carboxylase activity in vivo under fed and fasted conditions. Methods: [1- C]-labeled sodium L-lactate was polarized using...
9.
Chen J, Hackett E, Singh J, Kovacs Z, Park J
Anal Chem
. 2020 Aug;
92(17):11681-11686.
PMID: 32786486
Tissue pH is tightly regulated in vivo, being a sensitive physiological biomarker. Advent of dissolution dynamic nuclear polarization (DNP) and its translation to humans stimulated development of pH-sensitive agents. However,...
10.
Suh E, Hackett E, Wynn R, Chuang D, Zhang B, Luo W, et al.
Sci Rep
. 2019 Jan;
9(1):340.
PMID: 30674979
Altered branched-chain amino acids (BCAAs) metabolism is a distinctive feature of various cancers and plays an important role in sustaining tumor proliferation and aggressiveness. Despite the therapeutic and diagnostic potentials,...