Edward P Browne
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Explore the profile of Edward P Browne including associated specialties, affiliations and a list of published articles.
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50
Citations
1959
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Recent Articles
1.
Wang Y, Gornalusse G, Siegel D, Barbehenn A, Hoh R, Martin J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990376
Despite antiretroviral therapy (ART), people with HIV (PWH) on ART experience higher rates of morbidity and mortality vs. age-matched HIV negative controls, which may be driven by chronic inflammation due...
2.
Gray C, Ashokkumar M, Janssens D, Kirchherr J, Allard B, Hsieh E, et al.
bioRxiv
. 2024 Sep;
PMID: 39257755
The latent HIV reservoir is a major barrier to HIV cure. Combining latency reversal agents (LRAs) with differing mechanisms of action such as AZD5582, a non-canonical NF-kB activator, and I-BET151,...
3.
Semenova L, Wang Y, Falcinelli S, Archin N, Cooper-Volkheimer A, Margolis D, et al.
Elife
. 2024 Sep;
13.
PMID: 39250423
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure. Here, we...
4.
Ashokkumar M, Hafer T, Felton A, Archin N, Margolis D, Emerman M, et al.
bioRxiv
. 2024 Aug;
PMID: 39211204
Author Summary: HIV latency is a major obstacle for the eradication of HIV. However, molecular mechanisms that restrict proviral expression during therapy are not well understood. Identification of host cell...
5.
Ling L, Kim M, Soper A, Kovarova M, Spagnuolo R, Begum N, et al.
mBio
. 2024 Aug;
15(9):e0163224.
PMID: 39136440
The HIV reservoir is more dynamic than previously thought with around 70% of the latent reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral therapy (ART)....
6.
Ashokkumar M, Mei W, Peterson J, Harigaya Y, Murdoch D, Margolis D, et al.
Genomics Proteomics Bioinformatics
. 2024 Jun;
22(1).
PMID: 38902848
Despite the success of antiretroviral therapy, human immunodeficiency virus (HIV) cannot be cured because of a reservoir of latently infected cells that evades therapy. To understand the mechanisms of HIV...
7.
Bussey-Sutton C, Ward A, Fox J, Turner A, Peterson J, Emery A, et al.
PLoS Pathog
. 2024 Jun;
20(6):e1012281.
PMID: 38848441
Understanding the mechanisms that drive HIV expression and latency is a key goal for achieving an HIV cure. Here we investigate the role of the SETD2 histone methyltransferase, which deposits...
8.
Fenton A, Archin N, Turner A, Joseph S, Moeser M, Margolis D, et al.
J Virol
. 2024 Feb;
98(3):e0179823.
PMID: 38376258
Although antiretroviral therapy (ART) is effective at suppressing HIV replication, a viral reservoir persists that can reseed infection if ART is interrupted. Curing HIV will require elimination or containment of...
9.
Peterson J, Lewis C, Burgos S, Manickam A, Xu Y, Rowley A, et al.
Cell Chem Biol
. 2023 Dec;
30(12):1617-1633.e9.
PMID: 38134881
A long-lived latent reservoir of HIV-1-infected CD4 T cells persists with antiretroviral therapy and prevents cure. We report that the emergence of latently infected primary CD4 T cells requires the...
10.
Semenova L, Wang Y, Falcinelli S, Archin N, Cooper-Volkheimer A, Margolis D, et al.
bioRxiv
. 2023 Nov;
PMID: 38014340
Understanding the interplay between the HIV reservoir and the host immune system may yield insights into HIV persistence during antiretroviral therapy (ART) and inform strategies for a cure. Here, we...