Edward M Merricks
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Explore the profile of Edward M Merricks including associated specialties, affiliations and a list of published articles.
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18
Citations
288
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Recent Articles
1.
Zarr V, Liou J, Merricks E, Davis T, Thomson K, Greger B, et al.
STAR Protoc
. 2025 Mar;
6(1):103659.
PMID: 40022738
Innovations in electrophysiological recordings and computational analytic techniques enable high-resolution analysis of neural traveling waves. Here, we present a protocol for the detection and analysis of traveling waves from multi-day...
2.
Goldberg A, Dovas A, Torres D, Pereira B, Viswanathan A, Das Sharma S, et al.
Neuron
. 2025 Jan;
PMID: 39837324
Gliomas are aggressive neoplasms that diffusely infiltrate the brain and cause neurological symptoms, including cognitive deficits and seizures. Increased mTOR signaling has been implicated in glioma-induced neuronal hyperexcitability, but the...
3.
Rifkin R, Wu X, Pereira B, Gill B, Merricks E, Michalak A, et al.
Neuropharmacology
. 2024 Dec;
265():110259.
PMID: 39662702
Tumor associated epilepsy is a common and debilitating co-morbidity of brain tumors, for which inadequate treatments are available. Additionally, animal models suggest a potential link between seizures and tumor progression....
4.
Zhu H, Michalak A, Merricks E, Agopyan-Miu A, Jacobs J, Hamberger M, et al.
bioRxiv
. 2024 Jul;
PMID: 39026706
Despite abundant evidence of functional networks in the human brain, their neuronal underpinnings, and relationships to real-time behavior have been challenging to resolve. Analyzing brain-wide intracranial-EEG recordings with video monitoring,...
5.
Merricks E, Deshpande S, Agopyan-Miu A, Smith E, Schlafly E, McKhann G, et al.
medRxiv
. 2024 Feb;
PMID: 38343792
There is active debate regarding how GABAergic function changes during seizure initiation and propagation, and whether interneuronal activity drives or impedes the pathophysiology. Here, we track cell-type specific firing during...
6.
Goldberg A, Dovas A, Torres D, Das Sharma S, Mela A, Merricks E, et al.
bioRxiv
. 2024 Jan;
PMID: 38293120
Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed of diffusely infiltrating tumor cells that intermingle with non-neoplastic cells in the tumor microenvironment, including neurons. Neurons are...
7.
Agopyan-Miu A, Merricks E, Smith E, McKhann 2nd G, Sheth S, Feldstein N, et al.
Brain
. 2023 Aug;
146(12):5209-5223.
PMID: 37536281
The relationship between clinically accessible epileptic biomarkers and neuronal activity underlying the transition to seizure is complex, potentially leading to imprecise delineation of epileptogenic brain areas. In particular, the pattern...
8.
Lee S, Deshpande S, Merricks E, Schlafly E, Goodman R, McKhann G, et al.
Commun Biol
. 2023 Mar;
6(1):317.
PMID: 36966217
The electrographic manifestation of neural activity can reflect the relationship between the faster action potentials of individual neurons and the slower fluctuations of the local field potential (LFP). This relationship...
9.
Juan E, Gorska U, Kozma C, Papantonatos C, Bugnon T, Denis C, et al.
Brain
. 2022 Nov;
146(1):109-123.
PMID: 36383415
Loss of consciousness is a hallmark of many epileptic seizures and carries risks of serious injury and sudden death. While cortical sleep-like activities accompany loss of consciousness during focal impaired...
10.
Schlafly E, Marshall F, Merricks E, Eden U, Cash S, Schevon C, et al.
J Neurosci
. 2022 Jul;
42(36):6966-6982.
PMID: 35906069
During human seizures, organized waves of voltage activity rapidly sweep across the cortex. Two contradictory theories describe the source of these fast traveling waves: either a slowly advancing narrow region...