Andrew J Trevelyan
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Explore the profile of Andrew J Trevelyan including associated specialties, affiliations and a list of published articles.
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59
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1638
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Recent Articles
1.
Trevelyan A, Marks V, Graham R, Denison T, Jackson A, Smith E
Brain
. 2025 Jan;
148(3):746-752.
PMID: 39745924
Brain stimulation has, for many decades, been considered as a potential solution for the unmet needs of the many people living with drug-resistant epilepsy. Clinically, there are several different approaches...
2.
Vaughan A, McMeekin L, Hine K, Stubbs I, Codadu N, Cockell S, et al.
eNeuro
. 2024 Apr;
11(5).
PMID: 38664009
Seizures are generally associated with epilepsy but may also be a symptom of many other neurological conditions. A hallmark of a seizure is the intensity of the local neuronal activation,...
3.
McLeod F, McDermott E, Mak S, Walsh D, Turnbull M, LeBeau F, et al.
Front Neurosci
. 2024 Mar;
18:1287228.
PMID: 38495109
Introduction: Expression of light sensitive ion channels by selected neurons has been achieved by viral mediated transduction with gene constructs, but for this to have therapeutic uses, for instance in...
4.
Merricks E, Deshpande S, Agopyan-Miu A, Smith E, Schlafly E, McKhann G, et al.
medRxiv
. 2024 Feb;
PMID: 38343792
There is active debate regarding how GABAergic function changes during seizure initiation and propagation, and whether interneuronal activity drives or impedes the pathophysiology. Here, we track cell-type specific firing during...
5.
Pracucci E, Graham R, Alberio L, Nardi G, Cozzolino O, Pillai V, et al.
Nat Commun
. 2023 Nov;
14(1):7108.
PMID: 37925453
Cortical activity patterns are strongly modulated by fast synaptic inhibition mediated through ionotropic, chloride-conducting receptors. Consequently, chloride homeostasis is ideally placed to regulate activity. We therefore investigated the stability of...
6.
Parrish R, Jackson-Taylor T, Voipio J, Trevelyan A
Physiol Rep
. 2023 Aug;
11(15):e15778.
PMID: 37537145
We recently reported that strong activation of the optogenetic chloride pump, halorhodopsin leads to a secondary redistribution of K ions into the cell, through tonically open, "leak" K channels. Here...
7.
Agopyan-Miu A, Merricks E, Smith E, McKhann 2nd G, Sheth S, Feldstein N, et al.
Brain
. 2023 Aug;
146(12):5209-5223.
PMID: 37536281
The relationship between clinically accessible epileptic biomarkers and neuronal activity underlying the transition to seizure is complex, potentially leading to imprecise delineation of epileptogenic brain areas. In particular, the pattern...
8.
Wenzel M, Huberfeld G, Grayden D, de Curtis M, Trevelyan A
Epilepsia
. 2023 May;
64 Suppl 3:S37-S48.
PMID: 37183507
A critical question regarding how focal seizures start is whether we can identify particular cell classes that drive the pathological process. This was the topic for debate at the recent...
9.
Trevelyan A, Graham R, Parrish R, Codadu N
Epilepsy Curr
. 2023 Mar;
23(1):38-43.
PMID: 36923333
Investigations into seizure initiation, in recent years, have focused almost entirely upon alterations of interneuronal function, chloride homeostasis, and extracellular potassium levels. In contrast, little attention has been directed toward...
10.
Parrish R, MacKenzie-Gray Scott C, Jackson-Taylor T, Grundmann A, McLeod F, Codadu N, et al.
J Neurosci
. 2023 Jan;
43(5):685-692.
PMID: 36639898
The movement of ions in and out of neurons can exert significant effects on neighboring cells. Here we report several experimentally important consequences of activation of the optogenetic chloride pump,...