Edward M Culbertson
Overview
Explore the profile of Edward M Culbertson including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
294
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Recent Articles
1.
Culbertson E, C Levin T
Cell Host Microbe
. 2024 Sep;
32(9):1466-1468.
PMID: 39265534
Two recent studies in Cell Host & Microbe (Cury et al. and van den Berg et al.) uncover cross-kingdom links between antiphage and antiviral immune defenses. Through reciprocal computational and...
2.
Culbertson E, C Levin T
PLoS Biol
. 2023 Dec;
21(12):e3002436.
PMID: 38064485
Animals use a variety of cell-autonomous innate immune proteins to detect viral infections and prevent replication. Recent studies have discovered that a subset of mammalian antiviral proteins have homology to...
3.
Culbertson E, C Levin T
bioRxiv
. 2023 Jul;
PMID: 37425898
Animals use a variety of cell-autonomous innate immune proteins to detect viral infections and prevent replication. Recent studies have discovered that a subset of mammalian antiviral proteins have homology to...
4.
Culbertson E, Culotta V
Semin Cell Dev Biol
. 2021 Jan;
115:19-26.
PMID: 33423931
The transition metal Cu is an essential micronutrient that serves as a co-factor for numerous enzymes involved in redox and oxygen chemistry. However, Cu is also a potentially toxic metal,...
5.
Culbertson E, Bruno V, Cormack B, Culotta V
Mol Microbiol
. 2020 Aug;
114(6):1006-1018.
PMID: 32808698
As part of the innate immune response, the host withholds metal micronutrients such as Cu from invading pathogens, and microbes respond through metal starvation stress responses. With the opportunistic fungal...
6.
Culbertson E, Khan A, Muchenditsi A, Lutsenko S, Sullivan D, Petris M, et al.
Metallomics
. 2020 Jan;
12(3):416-426.
PMID: 31976503
Animals carefully control homeostasis of Cu, a metal that is both potentially toxic and an essential nutrient. During infection, various shifts in Cu homeostasis can ensue. In mice infected with...
7.
Robinett N, Culbertson E, Peterson R, Sanchez H, Andes D, Nett J, et al.
J Biol Chem
. 2018 Dec;
294(8):2700-2713.
PMID: 30593499
Copper-only superoxide dismutases (SODs) represent a new class of SOD enzymes that are exclusively extracellular and unique to fungi and oomycetes. These SODs are essential for virulence of fungal pathogens...
8.
Besold A, Culbertson E, Nam L, Hobbs R, Boyko A, Maxwell C, et al.
Metallomics
. 2018 Sep;
10(12):1728-1742.
PMID: 30206620
Calprotectin is a potent antimicrobial that inhibits the growth of pathogens by tightly binding transition metals such as Mn and Zn, thereby preventing their uptake and utilization by invading microbes....
9.
Rossi D, Gleason J, Sanchez H, Schatzman S, Culbertson E, Johnson C, et al.
PLoS Pathog
. 2017 Dec;
13(12):e1006763.
PMID: 29194441
Until recently, NADPH oxidase (NOX) enzymes were thought to be a property of multicellularity, where the reactive oxygen species (ROS) produced by NOX acts in signaling processes or in attacking...
10.
Besold A, Gilston B, Radin J, Ramsoomair C, Culbertson E, Li C, et al.
Infect Immun
. 2017 Nov;
86(2).
PMID: 29133349
The opportunistic fungal pathogen acquires essential metals from the host, yet the host can sequester these micronutrients through a process known as nutritional immunity. How the host withholds metals from...