Edward K Mandell
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Explore the profile of Edward K Mandell including associated specialties, affiliations and a list of published articles.
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14
Citations
508
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Recent Articles
1.
Uribe D, Mandell E, Watson A, Martinez J, Leighton J, Ghosh S, et al.
PLoS One
. 2017 Jul;
12(7):e0179979.
PMID: 28727830
The receptor tyrosine kinases (RTKs) TYRO3, AXL and MERTK (TAM) have well-described oncogenic functions in a number of cancers. Notwithstanding, TAM RTKs are also potent and indispensable inhibitors of inflammation....
2.
Cox C, Mandell E, Stewart L, Lu R, Johnson D, McCarter S, et al.
Mol Biol Cell
. 2015 May;
26(14):2673-84.
PMID: 25995376
Contact-mediated inhibition of cell proliferation is an essential part of organ growth control; the transcription coactivator Yes-associated protein (YAP) plays a pivotal role in this process. In addition to phosphorylation-dependent...
3.
Lu R, Dalgalan D, Mandell E, Parker S, Ghosh S, Wilson J
Mol Biol Cell
. 2015 Feb;
26(8):1523-31.
PMID: 25694446
PKCι is essential for the establishment of epithelial polarity and the normal assembly of tight junctions. We find that PKCι knockdown does not compromise the steady-state distribution of most tight...
4.
Kusne Y, Carrera-Silva E, Perry A, Rushing E, Mandell E, Dietrich J, et al.
Sci Signal
. 2014 Aug;
7(338):ra75.
PMID: 25118327
Grade IV glioblastoma is characterized by increased kinase activity of epidermal growth factor receptor (EGFR); however, EGFR kinase inhibitors have failed to improve survival in individuals with this cancer because...
5.
Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, et al.
Mol Pain
. 2014 Jul;
10:45.
PMID: 24993495
Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to nerve...
6.
Parker S, Mandell E, Hapak S, Maskaykina I, Kusne Y, Kim J, et al.
Proc Natl Acad Sci U S A
. 2013 Aug;
110(35):14450-5.
PMID: 23940317
Atypical protein kinase C (aPKC) isoforms ζ and λ interact with polarity complex protein Par3 and are evolutionarily conserved regulators of cell polarity. Prkcz encodes aPKC-ζ and PKM-ζ, a truncated,...
7.
Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, et al.
Mol Pain
. 2013 Mar;
9:12.
PMID: 23510079
Background: Chronic pain is an important medical problem affecting hundreds of millions of people worldwide. Mechanisms underlying the maintenance of chronic pain states are poorly understood but the elucidation of...
8.
Lubin J, Rao T, Mandell E, Wuttke D, Lundblad V
Genetics
. 2013 Jan;
193(3):715-25.
PMID: 23307900
Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations...
9.
King T, Qu C, Okun A, Melemedjian O, Mandell E, Maskaykina I, et al.
Pain
. 2012 Apr;
153(6):1263-1273.
PMID: 22482911
Injuries can induce adaptations in pain processing that result in amplification of signaling. One mechanism may be analogous to long-term potentiation and involve the atypical protein kinase C, PKMζ. The...
10.
Mandell E, Gelinas A, Wuttke D, Lundblad V
Biochemistry
. 2011 Jun;
50(29):6289-91.
PMID: 21668015
In the budding yeast Saccharomyces cerevisiae, chromosome end protection is provided by a heterotrimeric complex composed of Cdc13 in association with the RPA-like proteins Stn1 and Ten1. We report here...