Edward Hurrell
Overview
Explore the profile of Edward Hurrell including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
10
Citations
680
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Brown A, Bradley S, Marshall F, Brown G, Bennett K, Brown J, et al.
Cell
. 2021 Nov;
184(24):5886-5901.e22.
PMID: 34822784
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative...
2.
Borodovsky A, Barbon C, Wang Y, Ye M, Prickett L, Chandra D, et al.
J Immunother Cancer
. 2020 Jul;
8(2).
PMID: 32727810
Methods: We report here the development of a small molecule AR inhibitor including characterization of binding and inhibition of AR function with varying amounts of a stable version of adenosine....
3.
Langmead C, Andrews S, Congreve M, Errey J, Hurrell E, Marshall F, et al.
J Med Chem
. 2012 Jan;
55(5):1904-9.
PMID: 22250781
Virtual screening was performed against experimentally enabled homology models of the adenosine A(2A) receptor, identifying a diverse range of ligand efficient antagonists (hit rate 9%). By use of ligand docking...
4.
Congreve M, Andrews S, Dore A, Hollenstein K, Hurrell E, Langmead C, et al.
J Med Chem
. 2012 Jan;
55(5):1898-903.
PMID: 22220592
Potent, ligand efficient, selective, and orally efficacious 1,2,4-triazine derivatives have been identified using structure based drug design approaches as antagonists of the adenosine A(2A) receptor. The X-ray crystal structures of...
5.
Dore A, Robertson N, Errey J, Ng I, Hollenstein K, Tehan B, et al.
Structure
. 2011 Sep;
19(9):1283-93.
PMID: 21885291
Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via blockade of adenosine receptors. Xanthine analogs with improved...
6.
Robertson N, Jazayeri A, Errey J, Baig A, Hurrell E, Zhukov A, et al.
Neuropharmacology
. 2010 Jul;
60(1):36-44.
PMID: 20624408
G protein-coupled receptors (GPCRs) are one of the most important target classes in the central nervous system (CNS) drug discovery, however the fact they are integral membrane proteins and are...
7.
Hurrell E, Kucerova E, Loughlin M, Caubilla-Barron J, Hilton A, Armstrong R, et al.
BMC Infect Dis
. 2009 Sep;
9:146.
PMID: 19723318
Background: The objective of this study was to determine whether neonatal nasogastric enteral feeding tubes are colonised by the opportunistic pathogen Cronobacter spp. (Enterobacter sakazakii) and other Enterobacteriaceae, and whether...
8.
Townsend S, Hurrell E, Caubilla-Barron J, Loc-Carrillo C, Forsythe S
Microbiology (Reading)
. 2008 Dec;
154(Pt 12):3659-3667.
PMID: 19047733
Enterobacter hormaechei is a Gram-negative bacterium within the Enterobacter cloacae complex, and has been shown to be of clinical significance by causing nosocomial infections, including sepsis. Ent. hormaechei is spread...
9.
Townsend S, Hurrell E, Forsythe S
BMC Microbiol
. 2008 Apr;
8:64.
PMID: 18423002
Background: In 1994, an outbreak of Enterobacter sakazakii infections in France occurred in a neonatal intensive care unit during which 17 neonates were infected. More than half of the infected...
10.
Townsend S, Hurrell E, Gonzalez-Gomez I, Lowe J, Frye J, Forsythe S, et al.
Microbiology (Reading)
. 2007 Oct;
153(Pt 10):3538-3547.
PMID: 17906151
Enterobacter sakazakii is an opportunistic pathogen associated with contaminated powdered infant formula and a rare cause of Gram-negative sepsis that can develop into meningitis and brain abscess formation in neonates....